ArticleJournal of the Association for Research in Otolaryngology : JARO2025
Contributions of Auditory Nerve Density and Synchrony to Speech Understanding in Older Cochlear Implant Users.
Article in Journal of the Association for Research in Otolaryngology : JARO, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Evaluating the N1-P2 Interpeak Latency of the eCAP and Its Intertrial Variability as Potential Indicators of Neural Synchrony in the Auditory Nerve of Cochlear Implant Users.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Age-dependent Shifts in Spiral Ganglion Neuron Subtypes Are Associated with Interphase Gap-dependent Modulation of Electrically Evoked Compound Action Potentials in Mice.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Neural Hearing Loss: Mechanisms, Diagnosis and Treatment Horizons.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Establishing reliable neural health measures in adult cochlear implant users.Frontiers in neuroscience · 2026Article
- Evaluating the N1-P2 interpeak latency of the eCAP and its intertrial variability as potential indicators of neural synchrony in the cochlear nerve of cochlear implant users.medRxiv : the preprint server for health sciences · 2025Article
- Context effects for degraded speech: Effects of age, preceding or subsequent contextual cues, and signal-to-noise ratio.The Journal of the Acoustical Society of America · 2025Article
- Article
- The Failure Index as Marker of the Neural Health Profile in MED-EL CI Users: A Retrospective Analysis.Trends in hearingArticle
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Authors and funding
5 authors.
Funding
Abstract
purposeThe majority of adult cochlear implant (CI) recipients are over the age of 65, and previous research in non-implanted older adults shows that auditory nerve (AN) pathophysiology contributes to senescent declines in speech understanding. However, age-related changes to AN structure and function have not yet been explored as a contributory factor to poorer speech understanding outcomes in older CI users. Here, we explore how estimates of AN disengagement (i.e., AN density) and dyssynchrony in CI users contribute to poorer speech recognition performance observed in older CI users.
methodsWe examined electrically evoked compound action potentials (ECAPs) in 47 adult (Male = 25) CI recipients. We measured the interphase gap (IPG) effect for the amplitude-growth function (AGF) slope and the N1-P2 interpeak latency as independent metrics of AN density and dyssynchrony, respectively.
resultsEstimates of AN density and dyssynchrony worsen with increasing age in older CI listeners. These measures were not significantly correlated with one another, but were independently related to speech recognition in noise performance. Lower ECAP IPG effect values (lower density of AN fibers) are observed in older CI users. Longer N1-P2 interpeak latency values (poorer neural synchrony) are also observed in older CI users. When controlling for listener age, poorer AN dyssynchrony contributes to declines in speech-recognition-in-noise performance in CI users.
conclusionThese results suggest that AN dyssynchrony rather than density is the primary contributing factor to age-related declines in speech understanding in CI users. These results have important implications for better understanding neural contributions to speech understanding in adult CI users.
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