ArticleeLife2025
Annihilation of action potentials induces electrical coupling between neurons.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A historical review of ephaptic field research: from early foundations through contemporary renaissance.Frontiers in human neuroscience · 2026Review
- Structural and functional evidence for ephaptic control of Purkinje cell spike timing by networks of molecular layer interneurons.bioRxiv : the preprint server for biology · 2025Article
- Article
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Authors and funding
3 authors.
Funding
Abstract
Neurons generate and propagate electrical pulses called action potentials which annihilate on arrival at the axon terminal. We measure the extracellular electric field generated by propagating and annihilating action potentials and find that on annihilation, action potentials expel a local discharge. The discharge at the axon terminal generates an inhomogeneous electric field that immediately influences target neurons and thus provokes ephaptic coupling. Our measurements are quantitatively verified by a powerful analytical model which reveals excitation and inhibition in target neurons, depending on position and morphology of the source-target arrangement. Our model is in full agreement with experimental findings on ephaptic coupling at the well-studied Basket cell-Purkinje cell synapse. It is able to predict ephaptic coupling for any other synaptic geometry as illustrated by a few examples.
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Registered trials
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