Evidence map›Paper›PMID 40183774›Full record

ArticleeLife2025

Mesenchymal Meis2 controls whisker development independently from trigeminal sensory innervation.

Mehmet Mahsum Kaplan, Erika Hudacova, Miroslav Matejcek, Haneen Tuaima, Jan Křivánek, Ondrej Machon

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mehmet Mahsum KaplanDepartment of Developmental Biology, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic.ORCID https://orcid.org/0000-0002-3013-0848
Erika HudacovaDepartment of Developmental Biology, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic.
Miroslav MatejcekDepartment of Developmental Biology, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic.
Haneen TuaimaDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Jan KřivánekDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.ORCID https://orcid.org/0000-0002-7590-187X
Ondrej MachonDepartment of Developmental Biology, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic.ORCID https://orcid.org/0000-0002-5139-1406

Funding

Czech Science Foundation 22-10660SCzech Science Foundation 23-06160SEU Structural Funds Pro-NanoEnviCz CZ.02.1.01/0.0/0.0/16_013/0001821Masaryk University MUNI/A/1598/2023MEYS Czech Republic LM2018124MEYS Czech Republic NanoEnviCZ
6 · The paper itself

Abstract

Hair follicle development is initiated by reciprocal molecular interactions between the placode-forming epithelium and the underlying mesenchyme. Cell fate transformation in dermal fibroblasts generates a cell niche for placode induction by activation of signaling pathways WNT, EDA, and FGF in the epithelium. These successive paracrine epithelial signals initiate dermal condensation in the underlying mesenchyme. Although epithelial signaling from the placode to mesenchyme is better described, little is known about primary mesenchymal signals resulting in placode induction. Using genetic approach in mice, we show that

Indexed as

Homeodomain ProteinsMesodermTrigeminal NerveVibrissaeAnimalsForkhead Transcription FactorsGene Expression Regulation, DevelopmentalMiceNeural CrestForkhead Transcription FactorsFoxd1 protein, mouseHomeodomain Proteinscranial nervesdevelopmental biologyFoxd1hair follicle placodeMeis2mouseSox2whisker follicle

Identifiers

PMID40183774
PMCPMC11970903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.