Evidence map›Paper›PMID 40183773›Full record

ArticleeLife2025

CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells.

Xiaoyu Meng, Yezhang Zhu, Kuai Liu, Yuxi Wang, Xiaoqian Liu, Chenxin Liu, Yan Zeng, Shuai Wang, Xianzhi Gao, Xin Shen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xiaoyu Meng *Institute of Immunology and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yezhang Zhu *Department of Hematology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Kuai Liu *Institute of Immunology and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yuxi WangLaboratory Animal Center, Zhejiang University, Hangzhou, China.
Xiaoqian LiuInstitute of Immunology and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Chenxin LiuZhejiang University School of Medicine, Hangzhou, China.
Yan ZengInstitute of Immunology and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Shuai WangInstitute of Immunology and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xianzhi GaoInstitute of Immunology and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xin ShenCo-Facility Center, Zhejiang University School of Medicine, Hangzhou, China.
Jing ChenDepartment of Gastrointestinal Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Sijue TaoLaboratory Animal Center, Zhejiang University, Hangzhou, China.
Qianying XuZhejiang University School of Medicine, Hangzhou, China.
Linjia DongSchool of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, China.
Li ShenMOE Key Laboratory of Biosystems Homeostasis & Protection and Zhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0002-5696-2191
Lie WangInstitute of Immunology and Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID https://orcid.org/0000-0001-5094-012X

Funding

Central Universities in China 226-2024-00161National Key Research and Development Program of China 2022YFA1103200National Key Research and Development Program of China 2022YFA1103702National Key Research and Development Program of China 2023YFA1800202National Key Research and Development Program of China 2024YFF0728703National Natural Science Foundation of China 32030035National Natural Science Foundation of China 32100693National Natural Science Foundation of China 32270839National Natural Science Foundation of China 32321002National Natural Science Foundation of China 32341002National Science and Technology Major Project 2021ZD0200405Natural Science Foundation of Zhejiang Province LZ21C080001Natural Science Foundation of Zhejiang Province LZ23C070003Zhejiang University SZD202203
6 · The paper itself

Abstract

FOXP3-expressing regulatory T (T

Indexed as

Forkhead Transcription FactorsHomeostasisT-Lymphocytes, RegulatoryAnimalsGene Expression RegulationHistonesLymphocyte ActivationMiceMice, Inbred C57BLProtein BindingForkhead Transcription FactorsFoxp3 protein, mouseHistonesCXXC1epigenetic regulationFOXP3H3K4me3 broad domainimmunologyinflammationmouseTreg cell homeostasis

Identifiers

PMID40183773
PMCPMC11970909

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.