Evidence map›Paper›PMID 40183670›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2025

Hyperoxia-induced senescence in fetal airway smooth muscle cells: role of mitochondrial reactive oxygen species and endoplasmic reticulum stress.

Maunick L Koloko Ngassie, Michael A Thompson, Benjamin B Roos, Savita Ayyalasomayajula, Antony B Lagnado, João F Passos, Christina M Pabelick, Y S Prakash

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Dysregulated iron metabolism in remodeling of aging asthmatic human airways.American journal of physiology. Cell physiology · 2026
    Article
  2. Review
  3. Hyperoxia and iron homeostasis in developing human airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  4. Review
  5. Article
  6. Mitochondrial regulation of cellular senescence heterogeneity.Frontiers in cell and developmental biology · 2026
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maunick L Koloko NgassieDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0003-2899-3983
Michael A ThompsonDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Benjamin B RoosDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Savita AyyalasomayajulaDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.
Antony B LagnadoDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.
João F PassosDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.
Christina M PabelickDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-4632-2174
Y S PrakashDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-2968-224X

Funding

Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla · 2019 to 2026
$28.7M
NEURAL REGULATION OF AIRWAYS DURING POSTNATAL MATURATIONR01HL056470 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 1996 to 2025
$10.5M
Cellular Senescence in Neonatal AirwaysR01HL158532 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 2022 to 2025
$2.5M
Hydrogen Sulfide in Neonatal Airway DiseaseR01HL160570 · NHLBI · MAYO CLINIC ROCHESTER · PI Christina Maria Pabelick, Y. S. Prakash · 2023 to 2026
$2.4M
The role of sub-lethal mitochondrial apoptotic stress in cellular senescenceR01AG068048 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2020 to 2024
$2.2M
Cellular Senescence in Trisomy 21 lung diseaseR01HL171915 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Denise Al Alam, Christina Maria Pabelick · 2024 to 2026
$1.8M
Development of machine learning software to quantitatively map telomere induced senescence in tissue sections during agingUH3CA268103 · NCI · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2023 to 2025
$1.6M
Investigating the role of cytosolic mitochondrial double-stranded RNA in cellular senescence and agingR01AG082708 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2023 to 2025
$1.5M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL056470HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL158532HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL171915NCI NIH HHS UH3 CA268103NHLBI NIH HHS R01 HL056470NHLBI NIH HHS R01 HL158532NHLBI NIH HHS R01 HL160570NHLBI NIH HHS R01 HL171915NIA NIH HHS P01 AG062413NIA NIH HHS R01 AG068048NIA NIH HHS R01 AG082708NIH grant R01AG068048NIH grant UH3CA268103
6 · The paper itself

Abstract

Premature infants are at higher risk for developing chronic lung diseases, especially following supplemental oxygen (hyperoxia) in early life. We previously demonstrated that moderate hyperoxia (<60% O

Indexed as

Cellular SenescenceEndoplasmic Reticulum StressHyperoxiaMitochondriaMyocytes, Smooth MuscleReactive Oxygen SpeciesCells, CulturedCinnamatesFetusHumansMitochondrial DynamicsOrganophosphorus CompoundsOxidative StressQuinazolinonesThioureaUbiquinone3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinoneCinnamatesmitoquinoneOrganophosphorus CompoundsQuinazolinonesReactive Oxygen SpeciessalubrinalThioureaUbiquinonecellular senescenceDNA damageER stress responsemitochondria morphologyoxidative stress

Identifiers

PMID40183670
PMCPMC12173779

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.