ArticleNucleic acids research2025
Oxidative events in a double helix system promote the formation of kinetically trapped G-quadruplexes.
Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Binding of Tetrapentylammonium to a c-MYC G-quadruplex Depicted through NMR and Volumetric Assessment.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Base excision repair within structure-forming repeat sequences and its impact on cancer and other diseases.NAR cancer · 2025Review
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Authors and funding
3 authors.
Funding
Abstract
Guanine-rich oligonucleotide sequences can adopt four-stranded G-quadruplex structures. These sequences are highly susceptible to oxidative damage due to the low redox potential of their constituent guanine nucleotides. Oxidative lesions of guanine residue exhibit perturbations in the position of hydrogen-bond donors and acceptors, which can impair the formation of G-quadruplexes. Here we studied the effect of guanine oxidation in model systems comprised of a G-rich as well as a complementary C-rich DNA strand to discern how oxidative damage can destabilize double-stranded DNA and promote G-quadruplex formation. Our data show that G-rich strands containing oxidative lesions can still adopt the G-quadruplex fold due to the presence of spare G-tracts, which rescue the damaged G-tracts via either full or partial replacement. However, most of the observed G-quadruplexes are kinetically trapped structures and the preferred equilibrium state of the two-stranded constructs is double-stranded DNA.
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