Evidence map›Paper›PMID 40183578›Full record

ArticlemSphere2025

A response to iron involving carbon metabolism in the opportunistic fungal pathogen

Ritu Garg, Zhengkai Zhu, Francisco G Hernandez, Yiran Wang, Marika S David, Vincent M Bruno, Valeria C Culotta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The pathogenicity and future treatment strategies ofFrontiers in cellular and infection microbiology · 2026
    Review
  5. Frontiers in cellular and infection microbiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ritu GargDepartment of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Zhengkai ZhuDepartment of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Francisco G HernandezDepartment of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Yiran WangDepartment of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Marika S DavidDepartment of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Vincent M BrunoDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-1683-2015
Valeria C CulottaDepartment of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-3213-1326

Funding

Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI DUNNING HOTOPP, JULIE · 2014 to 2023
$36.5M
TRAINING IN AREAS FUNDAMENTAL TO CANCER RESEARCHT32CA009110 · NCI · JOHNS HOPKINS UNIVERSITY · PI MATUNIS, MICHAEL J., WEERARATNA, ASHANI T · 1985 to 2025
$13.1M
Training: Molecular & Cellular Bases of Infectious DiseasesT32AI007417 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Arturo Casadevall · 1994 to 2026
$11.9M
Therapeutic targeting of growth factor receptors to treat MucormycosisR01AI141360 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI BRUNO, VINCENT MICHAEL · 2019 to 2023
$2.5M
Cuproproteins for Redox BiologyR35GM136644 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI CULOTTA, VALERIA C · 2020 to 2024
$2.2M
Metal nutrients and metallophore-likemolecules for a fungal pathogenR21AI154726 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CULOTTA, VALERIA C · 2021 to 2022
$450k
NCI NIH HHS T32 CA009110NIAID NIH HHS R01 AI141360NIAID NIH HHS R21 AI154726NIAID NIH HHS T32 AI007417NIAID NIH HHS U19 AI110820NIGMS NIH HHS R35 GM136644NIH HHS R01 AI141360NIH HHS R21 AI54726NIH HHS R35 GM136644NIH HHS U19 AI110820
6 · The paper itself

Abstract

Iron (Fe) is an essential micronutrient, and during infection, the host attempts to starve pathogens of this vital element through a process known as nutritional immunity. Successful pathogens have evolved means to evade this attack, an example being IMPORTANCE: We describe a new response to Fe-starvation in a fungal pathogen involving carbon metabolism. Pyruvate dehydrogenase (PDH) that is central to glucose metabolism is inactivated at the post-translational level in Fe-starved cells. Nevertheless, the fungal pathogen can thrive by activating backup systems for metabolizing glucose. Methods that inhibit these compensatory pathways for carbon metabolism may prove beneficial in future anti-fungal strategies.

Indexed as

Candida albicansCarbonIronFungal ProteinsGene Expression Regulation, FungalGlycolysisPyruvate Dehydrogenase ComplexSaccharomyces cerevisiaeCarbonFungal ProteinsIronPyruvate Dehydrogenase Complexfungal pathogenironlipoylationmetabolismpyruvate dehydrogenase

Identifiers

PMID40183578
PMCPMC12039268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.