Evidence map›Paper›PMID 40183399›Full record

ReviewMolecular medicine reports2025

Role of DNA methylation and non‑coding RNAs expression in pathogenesis, detection, prognosis, and therapy‑resistant ovarian carcinoma (Review).

Victor M Del Castillo Falconi, Jenny A Godinez Rodriguez, Verónica Fragoso-Ontiveros, Laura Contreras-Espinosa, Abraham Pedroza-Torres, José Díaz-Chávez, Luis A Herrera

Abstract readReview
In one paragraph

Review in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Victor M Del Castillo FalconiCarcinogenesis Laboratory, Biomedical Cancer Research Unit of Biomedicine ‑ National Autonomous University of Mexico (UNAM), National Cancer Institute (INCan), Mexico City 14080, Mexico.
Jenny A Godinez RodriguezCelular Biology Department of Science Faculty, UNAM, Mexico City 04510, Mexico.
Verónica Fragoso-OntiverosCarcinogenesis Laboratory, Biomedical Cancer Research Unit of Biomedicine ‑ National Autonomous University of Mexico (UNAM), National Cancer Institute (INCan), Mexico City 14080, Mexico.
Laura Contreras-EspinosaCarcinogenesis Laboratory, Biomedical Cancer Research Unit of Biomedicine ‑ National Autonomous University of Mexico (UNAM), National Cancer Institute (INCan), Mexico City 14080, Mexico.
Abraham Pedroza-TorresInvestigadores por México Program ‑ SECIHTI, Hereditary Cancer Clinic, INCan, Mexico City 14080, Mexico.
José Díaz-ChávezCarcinogenesis Laboratory, Biomedical Cancer Research Unit of Biomedicine ‑ National Autonomous University of Mexico (UNAM), National Cancer Institute (INCan), Mexico City 14080, Mexico.
Luis A HerreraCarcinogenesis Laboratory, Biomedical Cancer Research Unit of Biomedicine ‑ National Autonomous University of Mexico (UNAM), National Cancer Institute (INCan), Mexico City 14080, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer is the deadliest gynecological cancer globally, with epithelial ovarian cancer (EOC) comprising up to 90% of cases. A molecular characterization linking the histological subtypes with tumor grade in EOC has been suggested. Variations in genetic biomarkers such as BRCA1/2, MSH2, MLH1/6, BRIP1, and RAD51C/D have been studied in EOC. In addition, molecular characteristics, including DNA methylation and RNA transcription, are being explored as potential new biomarkers for the diagnosis and prognosis of this type of neoplasia. The present review focused on the role of DNA methylation and non‑coding RNA expression in the development of ovarian carcinomas and their association with diagnosis, prognosis, and the resistance of cancer cells to radiotherapy and chemotherapy. The present review considered the transition from the DNA structure to the RNA expression in ovarian carcinoma.

Indexed as

Carcinoma, Ovarian EpithelialDNA DemethylationDrug Resistance, NeoplasmOvarian NeoplasmsRadiation ToleranceRNA, UntranslatedBiomarkers, TumorFemaleGenetic MarkersHumansPrognosisTranscription, GeneticBiomarkers, TumorGenetic MarkersRNA, UntranslatedbiomarkersDNA methylationlncRNAsmiRNAsovarian carcinomas

Identifiers

PMID40183399
PMCPMC11979574

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.