Evidence map›Paper›PMID 40183388›Full record

ArticleMolecular medicine reports2025

Multifunctional cosmetic potential of extracellular vesicle‑like nanoparticles derived from the stem of

Hyeon Jin Lee, Yun Hye Kim, Seo Jun Lee, Su Hyun Park, Jae-Min Yuk, Jae Cheol Jeong, Young Bae Ryu, Woo Sik Kim

Abstract read
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hyeon Jin LeeFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, North Jeolla 56212, Republic of Korea.
Yun Hye KimFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, North Jeolla 56212, Republic of Korea.
Seo Jun LeeFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, North Jeolla 56212, Republic of Korea.
Su Hyun ParkFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, North Jeolla 56212, Republic of Korea.
Jae-Min YukDepartment of Medical Science, College of Medicine, Chungnam National University, Daejeon, South Chungcheong 35015, Republic of Korea.
Jae Cheol JeongBiological Resource Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, North Jeolla 56212, Republic of Korea.
Young Bae RyuFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, North Jeolla 56212, Republic of Korea.
Woo Sik KimFunctional Biomaterial Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, North Jeolla 56212, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While natural products and synthetic chemicals are used in functional cosmetics, their potential side effects remain a concern. This has driven the need for safer and more effective agents to treat skin disorders. This has driven the need safer and more effective agents to treat skin disorders. Therefore, the present study aimed to explore the functional properties of Cannabis sativa stem‑derived nanoparticles (CSS‑NPs) and evaluate their potential as a cosmetic ingredient. Using nanoparticle analysis, CSS‑NPs, with a mean diameter of ~120 nm exhibited notable resistance to external stress conditions, including pH fluctuation and enzymatic degradation by DNase, RNase and proteinase K. They also contained 48 distinct biochemical components.

Indexed as

CannabisCosmeticsExtracellular VesiclesNanoparticlesPigmentation DisordersPlant Stemsalpha-MSHAnimalsCell Line, TumorCell SurvivalMelaninsMelanoma, ExperimentalMiceReactive Oxygen SpeciesSkin Pigmentationalpha-MSHCosmeticsMelaninsReactive Oxygen Speciesanti‑­melanogenic effectantioxidant activityCannabis sativamelaninmelanocyte stimulating hormonepigmentation disorderplant‑derived nanoparticle

Identifiers

PMID40183388
PMCPMC11980535

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.