ArticleJournal of cell science2025
Cell deformations generated by stochastic actomyosin waves drive in vivo random-walk swimming migration.
Article in Journal of cell science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Harnessing the Power ofCold Spring Harbor perspectives in biology · 2026Review
- The adipose tissue has an apical-basal polarity required for Col IV-dependent cell-cell adhesion.The Journal of cell biology · 2026Article
- Cellular gatekeepers of infected wounds: the dual role of adipocytes in coordinating immunity and regeneration.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Amoeboid cell migration drives many developmental and disease-related processes, including immune responses and cancer metastasis. Swimming migration is a subtype of amoeboid migration that is observed in cells in suspension ex vivo. However, the mechanism underlying swimming migration in vivo is unknown. Using Drosophila fat body cells (FBCs) as a model, we show that FBCs actively swim to patrol the pupa by random walk. Their migration is powered through actomyosin waves that exert compressive forces as they travel to the cell rear, causing cell deformations. Unlike in other types of amoeboid migration, Rho1 (the Drosophila orthologue of RhoA), Cdc42 and Rac1 are all required for regulation of formin-driven actin polymerization during FBC migration. We find that Rho1 at the cell rear induces actomyosin contractions via Rho kinase and myosin II. We show that contractile actin waves display a stochastic behaviour, inducing either cell elongation or rounding, suggesting that non-reciprocal cell deformations drive locomotion. Importantly, our work in a physiological system reveals that stochastic actomyosin waves promote random-walk swimming migration to enable fast, long-range cell dispersal. We propose that this individualist migration behaviour collectively allows patrolling of the pupal body.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.