ArticleCurrent aging science2026
Establishing Cut-off Points for the Cornell Scale to Enhance Depression Diagnosis in Parkinson's Disease Patients: A Study in the Vietnamese Healthcare Context.
Article in Current aging science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Clinical Outcome Assessments in Parkinson's Disease: A Scoping Review of Current Rating Scales and Future Needs.Movement disorders clinical practice · 2026Article
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Abstract
introductionMajor Depressive Disorder (MDD) often coexists with Parkinson's Disease (PD), significantly affecting the quality of life. Depression in Parkinson's disease patients is frequently neglected due to an emphasis on motor symptoms, resulting in underdiagnosis. The Cornell Scale for Depression in Dementia (CS) demonstrates potential as a screening instrument for identifying depression in Parkinson's disease patients, while research on its use in Vietnam is scarce.
methodsIn this cross-sectional study conducted at Nguyen Tri Phuong Hospital from February to September 2022, 54 patients with Parkinson's disease were examined for major depressive disorder according to DSM-5 criteria and evaluated using the CS. Reliability was assessed by inter-rater reliability testing. The diagnostic performance was assessed by calculating sensitivity, specificity, positive and negative predictive values, and the Area Under the Receiver Operating Characteristic (AUROC) curve.
resultsThe CS exhibited significant reliability (Cronbach's alpha = 0.91; ICC = 0.91) and diagnostic precision (AUROC = 0.968). An ideal cut-off score of 9 was determined, exhibiting a sensitivity of 88.5% and a specificity of 89.3%. The results indicated cut-off scores of 6 and 11 for excluding or diagnosing depression, respectively, affirming the CS as a versatile and efficient screening instrument for patients with Parkinson's disease. DISCUSSION: This scale has demonstrated reliability across studies, although the optimal cut-off points may vary slightly. It is suitable for community screening, outpatient preliminary diagnosis, or descriptive epidemiological surveys-allowing clinicians to select the most appropriate threshold based on specific clinical needs.
conclusionThe CS is a dependable and valid screening tool for identifying depression in Vietnamese PD patients, enabling early detection and intervention.
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