Evidence map›Paper›PMID 40183189›Full record

ArticleBJOG : an international journal of obstetrics and gynaecology2025

An In-Depth Analysis and Classification of Placental Causes of Stillbirth: A 10-Year Retrospective Study of a Regional Stillbirth Registry.

Leila Caillault, Rémi Béranger, Philippe Loget, Pauline Blanc-Petitjean, Maela Le Lous, Gwenaelle Le Bouar, Alain Lescoat, Ronan Garlantézec, Nicolas Belhomme, Ille et Vilaine stillbirth study group

Abstract read
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In one paragraph

Article in BJOG : an international journal of obstetrics and gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026
    Article
  3. [Establish Standardized Pathological and Genetic Examinations to Reduce the Incidence of Stillbirth].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leila CaillaultDepartment of Internal Medicine, Rennes University Hospital, Rennes, France.ORCID https://orcid.org/0000-0002-5699-7124
Rémi BérangerCHU Rennes, Inserm, EHESP, IRSET (Institut de Recherche en santé, Environnement et Travail), Univ Rennes, Rennes, France.
Philippe LogetDepartment of Pathology, Rennes University Hospital, Rennes, France.
Pauline Blanc-PetitjeanCHU Rennes, Inserm, EHESP, IRSET (Institut de Recherche en santé, Environnement et Travail), Univ Rennes, Rennes, France.
Maela Le LousDepartment of Obstetrics and Gynaecology, Rennes University Hospital, Rennes, France.ORCID https://orcid.org/0000-0001-6823-2279
Gwenaelle Le BouarDepartment of Obstetrics and Gynaecology, Rennes University Hospital, Rennes, France.
Alain LescoatDepartment of Internal Medicine, Rennes University Hospital, Rennes, France.
Ronan GarlantézecCHU Rennes, Inserm, EHESP, IRSET (Institut de Recherche en santé, Environnement et Travail), Univ Rennes, Rennes, France.
Nicolas BelhommeDepartment of Internal Medicine, Rennes University Hospital, Rennes, France.ORCID https://orcid.org/0000-0002-9438-3350
Ille et Vilaine stillbirth study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAbnormal placental lesions are commonly identified in stillbirth. Interpreting these lesions and their contribution to fetal demise presents significant challenges. Recommended CODAC classification does not include detailed placental examination results.

objectiveThis study reports abnormal placental patterns in relation to the distribution of stillbirth causes in order to refine the categories of causes.

designData from the Ille-Et-Vilaine Stillbirth cohort, an exhaustive register of stillbirth cases across the Ille-et-Vilaine French department, were implemented in 2010.

settingAll seven maternity wards in the Ille-et-Vilaine department, France. POPULATION: All cases of stillbirth located in the Ille-et-Vilaine department between 2010 and 2019.

methodsDescriptive statistics were used with the chi-squared test.

main outcome measuresAll placental examinations were reported following the Amsterdam consensus. Cause of death was ascertained according to the CODAC (Classification of Cause of Death and Associated Conditions) classification during multidisciplinary meetings.

resultsA total of 566 stillbirths were documented. The most frequent stillbirth causes were placental cause (36%), followed by umbilical cord (11%) and infections (9%). Stillbirth remained unexplained in 17% of cases. Small placenta and maternal malperfusion emerged as the most frequent placental lesions within the placental stillbirth group (65%), but also within the maternal cause groups (65%).

conclusionPlacental vascular anomalies were the most frequent cause of stillbirth in this study. Based on the combined use of international classification and observation of histological anomalies, our data suggest the existence of a vascular stillbirth group defined by vascular lesions associated with maternal or fetal expression.

Indexed as

PlacentaPlacenta DiseasesStillbirthAdultCause of DeathFemaleFranceHumansPregnancyRegistriesRetrospective Studiesplacental pathologystillbirthuteroplacental insufficiency

Identifiers

PMID40183189
PMCPMC12137759

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.