Evidence map›Paper›PMID 40183058›Full record

ArticlePeerJ2025

A proof-of-concept point-of-care test for the serodiagnosis of human amebic liver abscess.

Rutchanee Rodpai, Penchom Janwan, Lakkhana Sadaow, Patcharaporn Boonroumkaew, Oranuch Sanpool, Tongjit Thanchomnang, Hiroshi Yamasaki, Toshihiro Mita, Pewpan M Intapan, Wanchai Maleewong

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Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rutchanee RodpaiMekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Penchom JanwanMekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Lakkhana SadaowMekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Patcharaporn BoonroumkaewMekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Oranuch SanpoolMekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Tongjit ThanchomnangMekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Hiroshi YamasakiDepartment of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan.
Toshihiro MitaDepartment of Tropical Medicine and Parasitology, Juntendo University School of Medicine, Tokyo, Japan.
Pewpan M IntapanMekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.
Wanchai MaleewongMekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Amebic liver abscess (ALA), caused by an extraintestinal invasion of the virulent protozoan Methods: Both methods were tested to assess their diagnostic performance using a total of 253 serum samples. These came from ALA patients ( Results: Amebiasis-ICT exhibited 100% (95% confidential interval (CI) [75.3-100.0]) sensitivity and 97.1% (95% CI [94.1-98.8]) specificity, whereas ELISA gave the same sensitivity (100% 95% CI [75.3 -100.0]) and slightly lower specificity (95.8% 95% CI [92.5-98.0]). There were no significant differences in sensitivity and specificity between the two tests (Exact McNemar's test; Conclusion: This ICT tool using simulated whole-blood samples has a high possibility of being used with real whole blood. Therefore, since there is no need to separate serum, this can be considered an innovative diagnostic tool to replace serum-based ELISA in clinics and field surveys in remote areas where medical facilities are limited.

Indexed as

Chromatography, AffinityEntamoeba histolyticaLiver Abscess, AmebicPoint-of-Care TestingSerologic TestsAdultAntibodies, ProtozoanEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GMaleMiddle AgedProof of Concept StudySensitivity and SpecificityAntibodies, ProtozoanImmunoglobulin GAmebic liver abscessEntamoeba histolyticaEnzyme-linked immunosorbent assayImmunochromatographic testPoint-of care testSerodiagnosis

Identifiers

PMID40183058
PMCPMC11967440

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.