Evidence map›Paper›PMID 40183055›Full record

ArticlePeerJ2025

Association of chromosomal aberrations in chromosomes 3 and 7, and P16 mutations with malignancy in salivary gland tumors.

Yanxia Wu, Zhiyue Xie, Nan Peng, Rui Zhou, Liang Zhao

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In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yanxia Wu *Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Zhiyue Xie *Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Nan PengDepartment of Pathology, Guangdong Province Key Laboratory of Molecular Tumor Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.ORCID 0009-0004-2284-2265
Rui ZhouDepartment of Pathology, Guangdong Province Key Laboratory of Molecular Tumor Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China.
Liang ZhaoDepartment of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Salivary gland tumors, a prevalent type of head and neck neoplasm, exhibit significant morphological diversity and overlapping features, complicating pathological diagnosis. Although fluorescence Methods: Gene probes (CSP3, CSP7, and GSP P16) were designed to detect P16 gene deletion, and polysomies of chromosomes 3 and 7. The FISH analysis was conducted on 22 malignant and 12 benign salivary gland tumor samples with complete clinical data. The study was expanded to 78 samples for further validation. Results: The CSP3, CSP7, and GSP P16 probes exhibited high specificity for salivary gland tumors, though CSP7 exhibited lower sensitivity. The combination of CSP3 and GSP P16 probes outperformed single-probe analysis or other probe combinations. Conclusion: The CSP3 and GSP P16 probe combination provides a highly sensitive and specific method for distinguishing malignant from benign salivary gland tumors.

Indexed as

Chromosome AberrationsChromosomes, Human, Pair 3Cyclin-Dependent Kinase Inhibitor p16MutationSalivary Gland NeoplasmsAdultAgedAged, 80 and overFemaleHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedSensitivity and SpecificityCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16Fluorescence in situ hybridizationPathological diagnosisSalivary gland tumors

Identifiers

PMID40183055
PMCPMC11967423

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