ArticleFrontiers in neurology2025
Key motor and non-motor features in early dementia with Lewy bodies.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies.Molecular neurodegeneration · 2025Review
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12 authors.
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Abstract
Objective: The objective of our study was to characterize early-stage dementia with Lewy bodies (DLB) focusing on motor and non-motor symptoms. Methods: This cross-sectional study prospectively included newly diagnosed DLB patients within 3 years of cognitive symptom onset. Comparisons were made with individuals with Parkinson's disease (PD), Alzheimer's disease (AD), and controls. Demographic and clinical data were collected, and motor and non-motor symptoms were assessed using structured interviews and validated scales and questionnaires. Results: A total of 107 participants were included (23 DLB, 27 PD, 26 AD, and 31 controls). DLB patients (median age 75 years, median disease duration since diagnosis 2 months) commonly reported motor symptoms, including gait disturbances (91.3%), tremor (73.9%), and bradykinesia (87%), with tremor being predominantly unilateral (76.5%) and action-type (52.9%). The most frequent motor subtype was akinetic-rigid (52.2%). Motor symptoms were similar to PD, except for more frequent falls (34.8% vs. 11.1%, Conclusion: Early-stage DLB closely resembles PD in motor symptoms but has more neuropsychiatric non-motor symptoms compared to PD and overall non-motor symptoms than AD.
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