Evidence map›Paper›PMID 40182843›Full record

ArticleFrontiers in medicine2025

Diagnosis of brain death and consecutive donor management under combined circulatory support with ECMELLA therapy.

Florian J Raimann, Laurent M Willems

Abstract read
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Florian J RaimannDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
Laurent M WillemsDepartment of Neurology and Epilepsy Center Frankfurt Rhine-Main, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Managing brain death determination (BDD) in potential organ donors is a challenging aspect of modern intensive care medicine. In critically ill patients with implanted circulatory or left ventricular support devices, standard recommendations for BDD are often no longer applicable. Methods/results: The available recommendations and evidence for BDD and organ procuring under ECMELLA therapy-a combined circulatory support using a veno-arterial extracorporeal membrane oxygenation (vaECMO) and an invasive left ventricular support device (Impella Conclusion: Although BDD in patients with multimodal invasive circulatory support, such as ECMELLA therapy, is demanding and time-intensive, it can still be performed safely and based on evidence. Given the continuing low numbers of organ donors, these insights may help to facilitate organ donation in patients with combined invasive mechanical circulatory support.

Indexed as

cardiac arrestcritical careECMOimpellaintensive careorgan donation

Identifiers

PMID40182843
PMCPMC11965667

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.