ArticleFrontiers in medicine2025
Effects of preemptive acupuncture on cognitive function of older patients after hip replacement: a randomized controlled trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Advances in electroacupuncture for perioperative neurocognitive disorders: mechanisms and clinical evidence.Chinese medicine · 2026Review
- Acupuncture-Mediated Neuro-Immune Regulation in Musculoskeletal Pain: Mechanisms and Therapeutic Perspectives.Journal of pain research · 2026Review
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Authors and funding
6 authors.
Funding
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Abstract
Background: Postoperative cognitive impairment is a common complication in older patients after major orthopedic surgery; however, the underlying mechanism is not completely understood. Objective: This study aimed to evaluate the effects of preemptive acupuncture on cognitive dysfunction after hip replacement and explore its potential mechanisms. Methods: Finally, 54 participants were randomized into sham acupuncture ( Results: Compared with the sham acup group, the MMSE and MoCA scores in the acup group on the first and seventh day after surgery were higher, and the incidence of POCD on the first day was lower. Acupuncture upregulated levels of miR-124 and -146a and decreased the levels of TNF- Conclusion: Acupuncture protects postoperative cognitive function in older patients undergoing hip replacement, potentially reducing the incidence of POCD by upregulating miR-124 and miR-146a to inhibit neuroinflammation. Clinical trial registration: www.chictr.org.cn, identifier ChiCTR2200062027.
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