ArticleVeterinary world2025
Effect of feeding
Article in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Multitarget Pharmacological Mechanisms and Safety Profiles of Six Ethnobotanically Prioritized Indonesian Medicinal Plants for Cardiometabolic Disorders: A Systematic Review.Drug design, development and therapy · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aim: Diabetic nephropathy (DN) is a major complication of diabetes mellitus characterized by oxidative stress and inflammation. Conventional treatments often fail to prevent its progression. This study investigates the therapeutic potential of Materials and Methods: Male Wistar rats (n = 24) were divided into four groups: control (saline), positive control (0.1% zinc oxide suspension), treatment (TDNP at 100 mg/kg body weight), and comparison (quercetin at 5 mg/kg body weight). DN was induced using STZ and nicotinamide. Blood glucose, creatinine, urea, gamma-glutamyl transferase (γ-GT), and high-density lipoprotein cholesterol levels were assessed. Oxidative stress markers (superoxide dismutase [SOD], glutathione peroxidase [GPx]), inflammatory cytokines (TNF-α), and immunohistochemical indicators (anti-insulin, interferon-gamma [IFN-γ]) were measured. Data were analyzed using a one-way analysis of variance and Kruskal-Wallis tests. Results: TDNP treatment significantly reduced blood glucose, creatinine, urea, γ-GT, and TNF-α levels (p ≤ 0.05), while increasing SOD, GPx, and anti-insulin levels compared with the positive control. Histopathological analysis showed decreased necrosis and inflammation in pancreatic and renal tissues. Immunohistochemistry revealed enhanced anti-insulin and reduced IFN-γ expression in TDNP-treated rats, indicating improved immune regulation and oxidative stress mitigation. Conclusion: TDNP demonstrates potent antioxidative and anti-inflammatory effects, effectively improving glucose metabolism and kidney function in DN. These findings highlight TDNP as a promising therapeutic agent for managing DN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.