ArticleJournal of public health in Africa2025
Screening for monoclonal gammopathies of undetermined significance: A prospective study.
Article in Journal of public health in Africa, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Several studies have reported an increase in the incidence of multiple myeloma among farmers following pesticide use. Aim: This study aimed to seek an association between pesticide exposure and monoclonal gammopathy of undetermined significance (MGUS) in young pesticide applicators. Setting: The setting for this study was the Souss Massa region of the Kingdom of Morocco. Methods: We conducted a case-control study among 239 young male pesticide applicators with known exposure to pesticides (male pesticide applicators = exposed group) and 157 males with no direct exposure to pesticides (unexposed group). Serum protein electrophoresis was performed on all sera, and when monoclonal proteins were detected, they were characterised by serum protein immunofixation electrophoresis. Results: We found that the prevalence of MGUS was significantly higher in the exposed group older than 40 years 4.03% (95% confidence interval [CI]: 1.49-9.62) compared with the control group 0.91% (95% CI: 0.16-4.97), with no cases reported before this age. However, the odds ratio did not reach statistical significance 3.33 (95% CI: 0.39-28.78), which can be explained by the size of the population and the mean age ± s.d. of the pesticide applicators of 39.54 ± 11.51. In contrast, the international studies found the same results with all recruited patients over 50 years. This selection was made at the beginning of the study. Monoclonal proteins in the exposed group were characterised as follows: immunoglobulin Gλ 3 (1.25%), IgGκ 1 (0.41%) and biclonal IgGκ + IgGκ 1 (0.41%). Conclusion: We recommend mandatory screening for monoclonal gammopathy in pesticide applicators over the age of 40 years. Further studies are needed to investigate the association between pesticide molecules and MGUS. Contribution: The results of this study can be used by the Ministry of Health and the Ministry of Agriculture to provide baseline data to help develop appropriate prevention measures and awareness programmes against the misuse of pesticides.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.