ArticleBiology of sport2025
N-Lactoyl amino acids as metabolic biomarkers differentiating low and high exercise response.
Article in Biology of sport, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Lactate as a Chemical Modification on Proteins and Metabolites.Annual review of biochemistry · 2026Review
- Untargeted Metabolomics Identifies N-Lactoyl-Amino Acids as Dose-Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes.Clinical pharmacology and therapeutics · 2026Article
- Lac-Phe: An Emerging Appetite-Regulating Exerkine with Health and Therapeutic Benefits.Current obesity reports · 2026Review
- N-Lactoyl amino acids: insights from metabolite genome-wide association studies and phenome-wide association analysis.Human molecular genetics · 2025Article
- N-lactoyl amino acids are potential biomarkers for insulin resistance and diabetic complications.Diabetes, obesity & metabolism · 2025Article
- N-Lactoyl Amino Acids: Emerging Biomarkers in Metabolism and Disease.Diabetes/metabolism research and reviews · 2025Review
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Authors and funding
8 authors.
Funding
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Abstract
Aerobic physical exercise has significant benefits for cardiovascular health; however, some individuals experience no benefit or even adverse effects. One reason for poor tolerance to aerobic exercise may be a low percentage of slow-twitch (oxidative) muscle fibers. This study aims to identify the metabolic signatures associated with low and high response to exercise by comparing the metabolic profiles of participants categorized according to their improvement of the 6-minute walking distance. In this study, pre- and postexercise intervention measurements of the 6-minute walking distance were conducted in forty-three lean and overweight young women, followed by non-targeted metabolomics analysis of 1039 known metabolites. An independent validation cohort comprising 791 individuals from the GTEx project was used to assess the gene expression of selected targets. The results indicated that a low improvement in the 6-minute walking distance (Δ 6-MWD = 27 meters) was associated with higher serum levels of N-lactoyl amino acid metabolites, particularly the exercise-inducible metabolite N-lactoyl phenylalanine (Lac-Phe) (FDR = 0.016), compared to high responders. Our results were corroborated in an independent validation cohort, which showed that the gene expression of cytosolic nonspecific dipeptidase (
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