Calibration of ventilation/perfusion match in electrical impedance tomography: a novel method based on arterial blood pressure.

Introduction: Electrical impedance tomography (EIT) enables non-invasive, continuous, bedside evaluation of ventilation/perfusion (V/Q) match. To avoid the presence of invasive monitoring for cardiac output in relative V/Q ratio calculation, we proposed a novel calibration method based on arterial blood pressure to optimize EIT V/Q match assessments. Methods: We involved 12 mechanically ventilated piglets in three experimental phases: baseline, pulmonary embolism, and atelectasis. After a thorough measurement of EIT signals, arterial blood pressure, cardiac output, and additional physiological parameters, EIT V/Q match was evaluated using existing area limited method (ALM), cardiac output calibrated method (COCM), and our proposed novel blood pressure calibrated method (BPCM). Finally, V Results: Arterial blood pressure waveform integration demonstrated strong correlation with cardiac output ( Conclusion: This study described a novel calibration method for calculating corrected EIT-based V/Q match that utilized arterial blood pressure. Our method exhibited comparable capability in distinguishing V/Q mismatch areas compared to conventional cardiac output-based calibration techniques. With clinical data to establish a linear regression model, our method will ultimately enable us to calculate calibrated EIT V/Q match without cardiac output monitoring.