Evidence map›Paper›PMID 40182658›Full record

ArticleMaterials today. Bio2025

Sustained slow-release TGF-β3 in a three-dimensional-printed titanium microporous scaffold composite system promotes ligament-to-bone healing.

Liwei Zhu, Yuzhe Liu, Yifu Sun, Zhenjia Che, Youbin Li, Tengyue Liu, Xudong Li, Chengzhe Yang, Lanfeng Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liwei ZhuDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, PR China.
Yuzhe LiuDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, PR China.
Yifu SunDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, PR China.
Zhenjia CheDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, PR China.
Youbin LiDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, PR China.
Tengyue LiuDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, PR China.
Xudong LiDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, PR China.
Chengzhe YangDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, PR China.
Lanfeng HuangDepartment of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment of tendon/ligament-to-bone injury is a long-standing research challenge in orthopedics and bone tissue engineering. Orderly healing of the fibrocartilage layer and mineralized bone layer is crucial for treating tendon-bone interface injuries. We designed a three-dimensional printed porous titanium scaffold composite system with thermosensitive collagen hydrogel loaded with transforming growth factor β3 (TGF-β3), formulated for the sustained slow release of TGF-β3 at a constant rate.

Indexed as

Bioactive interfaceSustained-release systemTendon/ligament-to-bone healingTitanium scaffoldsTransforming growth factor-β3

Identifiers

PMID40182658
PMCPMC11966733

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.