Evidence map›Paper›PMID 40182598›Full record

Trial reportWorld journal of gastroenterology2025

Randomized study of

I Nengah Sujaya, Mariyatun Mariyatun, Pratama Nur Hasan, Nancy Eka Putri Manurung, Putrika Citta Pramesi, Mohammad Juffrie, Tyas Utami, Muhammad Nur Cahyanto, Shuta Yamamoto, Takuya Takahashi and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

I Nengah SujayaSchool of Public Health, Faculty of Medicine, Udayana University, Denpasar 80230, Bali, Indonesia.
Mariyatun MariyatunCenter for Food and Nutrition Studies, Universitas Gadjah Mada, Sleman 55281, Daerah Istimewa Yogyakarta, Indonesia.
Pratama Nur HasanCenter for Food and Nutrition Studies, Universitas Gadjah Mada, Sleman 55281, Daerah Istimewa Yogyakarta, Indonesia.
Nancy Eka Putri ManurungCenter for Food and Nutrition Studies, Universitas Gadjah Mada, Sleman 55281, Daerah Istimewa Yogyakarta, Indonesia.
Putrika Citta PramesiCenter for Food and Nutrition Studies, Universitas Gadjah Mada, Sleman 55281, Daerah Istimewa Yogyakarta, Indonesia.
Mohammad JuffrieFaculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Sleman 55281, Daerah Istimewa Yogyakarta, Indonesia.
Tyas UtamiCenter of Excellence for Research and Application on Integrated Probiotics Industry, Universitas Gadjah Mada, Sleman 55281, Daerah Istimewa Yogyakarta, Indonesia.
Muhammad Nur CahyantoDepartment of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Gadjah Mada, Sleman 55281, Daerah Istimewa Yogyakarta, Indonesia.
Shuta YamamotoYakult Central Institute, Yakult Honsha Co., Ltd., Kunitachi 186-8650, Tōkyō, Japan.
Takuya TakahashiYakult Honsha European Research Center for Microbiology VOF, Ghent 9052, East Flanders, Belgium.
Takashi AsaharaYakult Central Institute, Yakult Honsha Co., Ltd., Kunitachi 186-8650, Tōkyō, Japan.
Takuya AkiyamaYakult Central Institute, Yakult Honsha Co., Ltd., Kunitachi 186-8650, Tōkyō, Japan.
Endang Sutriswati RahayuCenter for Food and Nutrition Studies, Universitas Gadjah Mada, Sleman 55281, Daerah Istimewa Yogyakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHealth maintenance in elderly houses includes management of the gut microbiota and the environment.

aimTo investigate the effect of LcS-fermented milk on the gut microbiota and environment of Indonesian elderly houses.

methodsThis double-blind, randomized, placebo-controlled trial involved 112 participants from Indonesian elderly houses, spanning a 2-week baseline and 24-week treatment. Participants were randomly assigned to probiotic or placebo groups, consuming fermented milk with or without LcS (> 6.5 × 10

resultsAnalyses of 16S rRNA gene sequence data at the 3-month period revealed increased

conclusionDaily intake of LcS positively affects the gut microbiota and environment of people living in Indonesian elderly houses.

Indexed as

Cultured Milk ProductsGastrointestinal MicrobiomeProbioticsAgedAged, 80 and overAnimalsDouble-Blind MethodFecesFemaleHousingHumansIndonesiaLacticaseibacillusMaleMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16SElderlyFermented milkIntestinal microbiotaLacticaseibacillus paracasei ShirotaProbiotics

Identifiers

PMID40182598
PMCPMC11962840

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.