Evidence map›Paper›PMID 40182589›Full record

ArticleWorld journal of gastroenterology2025

Characterization of gallbladder stones associated with occult pancreaticobiliary reflux using computed tomography.

Chen Qiu, Yu-Kai Xiang, Hai Hu, Xuan-Bo Da, Gang Li, Yue-Yi Zhang, Hong-Lei Zhang, Cheng Zhang, Yu-Long Yang

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Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Chen QiuCenter of Gallbladder Disease, Shanghai East Hospital, Institute of Gallstone Disease, Tongji University School of Medicine, Shanghai 200120, China.
Yu-Kai XiangCenter of Gallbladder Disease, Shanghai East Hospital, Institute of Gallstone Disease, Tongji University School of Medicine, Shanghai 200120, China.
Hai HuCenter of Gallbladder Disease, Shanghai East Hospital, Institute of Gallstone Disease, Tongji University School of Medicine, Shanghai 200120, China.
Xuan-Bo DaCenter of Gallbladder Disease, Shanghai East Hospital, Institute of Gallstone Disease, Tongji University School of Medicine, Shanghai 200120, China.
Gang LiCenter of Gallbladder Disease, Shanghai East Hospital, Institute of Gallstone Disease, Tongji University School of Medicine, Shanghai 200120, China.
Yue-Yi ZhangCenter of Gallbladder Disease, Shanghai East Hospital, Institute of Gallstone Disease, Tongji University School of Medicine, Shanghai 200120, China.
Hong-Lei ZhangCenter of Gallbladder Disease, Shanghai East Hospital, Institute of Gallstone Disease, Tongji University School of Medicine, Shanghai 200120, China.
Cheng ZhangCenter of Gallbladder Disease, Shanghai East Hospital, Institute of Gallstone Disease, Tongji University School of Medicine, Shanghai 200120, China.
Yu-Long YangCenter of Gallbladder Disease, Shanghai East Hospital, Institute of Gallstone Disease, Tongji University School of Medicine, Shanghai 200120, China. yyl516@tongji.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOccult pancreaticobiliary reflux (OPBR) is characterized by the absence of congenital anomalies at the pancreaticobiliary junction yet leads to altered bile composition and an increased incidence of gallbladder stones.

aimTo explore the computed tomography (CT) imaging characteristics of gallbladder stones in patients diagnosed with OPBR.

methodsWe analyzed 362 patients undergoing cholecystectomy (November 2020 to January 2022). Intraoperative bile samples were assayed for amylase (> 110 U/L indicated OPBR). CT features, including stone density and visibility, were compared between 54 OPBR and 308 controls. Stone attenuation (HU) was measured under standardized conditions (uCT-780, 120 kVp, 160 mAs). Logistic regression and receiver operating characteristic curve analysis identified independent OPBR predictors, forming a validated nomogram.

resultsOPBR patients exhibited significantly higher rates of CT-invisible stones (35.2%

conclusionCT imaging distinctly identifies gallbladder stone density, indicating a heightened risk of OPBR in patients with uniform and CT-invisible stones. Such imaging is crucial for preoperative assessments to evaluate potential recurrent biliary pathologies post-cholecystectomy.

Indexed as

Bile RefluxGallstonesTomography, X-Ray ComputedAdultAgedBileCholecystectomyFemaleGallbladderHumansMaleMiddle AgedNomogramsRetrospective StudiesROC CurveComputed tomographyDiagnostic modelOccult pancreaticobiliary refluxPancreaticobiliary maljunctionPancreaticobiliary reflux

Identifiers

PMID40182589
PMCPMC11962842

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.