Evidence map›Paper›PMID 40182583›Full record

ArticleJournal of diabetes and metabolic disorders2025

Linc-PINT downregulation of TGF-β signaling pathway in heart arrhythmia: an in silico analysis.

Arash Amin, Mahya Bakhshi Ardakani, Maryam Saadatakhtar, Aida Zeinali, Shana Ahadi, Azadeh Fateh, Zohreh Salehnassaj, Fatemeh Dadgar, Farnaz Khodaparast

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Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

9 authors.

Arash AminDepartment of Cardiology, School of Medicine, Shahid Madani Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran.
Mahya Bakhshi ArdakaniIran University of Medical Sciences, Tehran, Iran.
Maryam SaadatakhtarIslamic Azad University Central, Tehran Branch, Tehran, Iran.
Aida ZeinaliDepartment of Cardiology, Tehran University of Medical Sciences, Tehran, Iran.
Shana AhadiAhvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Azadeh FatehShahid Sadoughi University of Medical Sciences, Yazd, Iran.
Zohreh SalehnassajCenter for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran.
Fatemeh DadgarDepartment of Internal Medicine, Lorestan University of Medical Science, Khorramabad, Iran.
Farnaz KhodaparastDepartment of Cardiovascular, School of Medicine, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart Arrhythmias (HA) is one of the heart diseases that occurs due to heart dysfunction or contraction of myocardial cells. Long non-coding RNAs (LncRNAs) are one of the factors that play a role in the physiopathology of HA. TGF-β plays a pivotal role in the pathogenesis of HA. Recently, it has been shown that linc-PINT can play a role in regulating TGF-β expression. However, the interaction of these two molecules in HA has not been investigated in silico, so we evaluated this issue in this study. We accessed the GSE133420 (platform: GPL20795 HiSeq X Ten (Homo sapiens)) dataset containing RNA-seq data from human atrial appendage tissues from patients with atrial fibrillation (AF) and healthy controls. It deals with RNA isolates obtained from plasma samples. To identify potential binding sites for linc-PINT within the promoters of TGF-β signaling genes, we used LncRRIsearch. To further validate and supplement these predictions, we also referenced target genes from LncTar and starBase, which were then integrated into the protein-protein interaction (PPI) network. The results showed that the expression of linc-PINT was significantly decreased in patients compared to the control group ( Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-025-01609-5.

Indexed as

Computational modelingGene expressionHeart arrhythmiaIn silico analysislinc-PINTNetwork analysisTGF-β

Identifiers

PMID40182583
PMCPMC11961773

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