Evidence map›Paper›PMID 40182519›Full record

ArticleFrontiers in public health2025

The epidemiology and burden of respiratory syncytial virus and influenza infections in hospitalized children under 5 years old in Zhejiang, China (2018-2023).

Wanwan Sun, Qiuyao Duan, Lei Guo, An Zhu, An Tang, Ziping Miao, Yu Zhang, Fen Yuan, Xiaofei Fu, Suyan Shi and 11 more

Abstract read
In one paragraph

Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Wanwan Sun *Zhejiang Key Lab of Vaccine, Department of Infectious Diseases, Infectious Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Qiuyao Duan *School of Public Health, Xiamen University, Xiamen, Fujian, China.
Lei Guo *Department of Infection Control, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
An ZhuDepartment of Pediatrics, Second People's Hospital of Jinyun County (Huzhen Branch of Lishui Central Hospital), Lishui, China.
An TangDepartment of Infectious Diseases, Zhoushan Center for Disease Control and Prevention, Zhoushan, China.
Ziping MiaoZhejiang Key Lab of Vaccine, Department of Infectious Diseases, Infectious Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Yu ZhangDepartment of Infectious Diseases, Zhoushan Center for Disease Control and Prevention, Zhoushan, China.
Fen YuanTonglu Maternal and Child Health Center, Hangzhou, China.
Xiaofei FuDepartment of Infectious Diseases, Jiaxing Center for Disease Control and Prevention, Jiaxing, China.
Suyan ShiThe Second People's Hospital of Tonglu County, Hangzhou, China.
Lan WangDepartment of Geriatrics, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Shijian LiDepartment of Public Health, The State University of New York at Old Westbury, New York, NY, United States.
XiaoZhi XuDepartment of Pediatrics, Second People's Hospital of Jinyun County (Huzhen Branch of Lishui Central Hospital), Lishui, China.
Chunlei ZhuDepartment of Pediatrics, Second People's Hospital of Jinyun County (Huzhen Branch of Lishui Central Hospital), Lishui, China.
Lefei ZhouDepartment of Pediatrics, Second People's Hospital of Jinyun County (Huzhen Branch of Lishui Central Hospital), Lishui, China.
Li RuiDepartment of Infectious Diseases, Jiaxing Center for Disease Control and Prevention, Jiaxing, China.
Pang YueDepartment of Infectious Diseases, Jiaxing Center for Disease Control and Prevention, Jiaxing, China.
Zhao YuZhejiang Key Lab of Vaccine, Department of Infectious Diseases, Infectious Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Jinren PanZhejiang Key Lab of Vaccine, Department of Infectious Diseases, Infectious Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Chaorong NiDepartment of Infectious Diseases, Wenzhou Center for Disease Control and Prevention, Wenzhou, China.
Shelan LiuZhejiang Key Lab of Vaccine, Department of Infectious Diseases, Infectious Disease Prevention and Control, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Estimate changes in hospital-based respiratory syncytial virus (RSV) disease burden before and after the COVID-19 pandemic and compare this burden with influenza among children younger than 5 years old in China's Zhejiang Province. Methods: We enrolled hospitalized children under 5 years old from eight hospitals in Zhejiang Province. Multiple testing methods were used to compare epidemiological characteristics, and multivariate logistic regression analyses were used to estimate the odds ratio (OR) and 95% confidence interval (CI) between the two groups. Results: In this study, of the 7,857 RSV and 2,571 influenza patients, the median age of the children was significantly lower for RSV infection than for influenza. Inpatients with RSV had longer hospitalization durations (mean: 5.66 days vs. 5.04 days; Conclusion: RSV is a significant contributor to disease burden in hospitalized children under 5 years old, outweighing influenza. The COVID-19 pandemic impacted the epidemiological characteristics and disease burden of hospitalization for RSV and influenza infections. A more effective prevention strategy for both infections in young children, especially vaccinations against RSV and influenza, is urged.

Indexed as

Cost of IllnessCOVID-19HospitalizationInfluenza, HumanRespiratory Syncytial Virus InfectionsChild, PreschoolChinaFemaleHumansInfantInfant, NewbornMalePandemicschildrendisease burdeninfluenza viruspneumoniarespiratory syncytial virus

Identifiers

PMID40182519
PMCPMC11966739

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.