ReviewJournal of maxillofacial and oral surgery2025
Field Cancerisation in Oral Squamous Cell Carcinoma Patients: A Systematic Review.
Review in Journal of maxillofacial and oral surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Global Prevalence of Oral Potentially Malignant Disorders: An Updated Systematic Review and Meta-Analysis.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Pooled it
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Field cancerisation refers to molecular level cancerous changes that occurs in clinically normal looking tissue. In oral cavity, widespread exposure to carcinogens like tobacco/alcohol makes the entire mucosa susceptible to malignant changes. This manifests as local recurrence and/second primary after initial treatment of primary tumours. The purpose of this review is to identify the most commonly used marker in oral cavity field cancerisation and also to find out its prognostic significance. Materials and method: Systematic review was conducted following PRISMA guidelines. Literature search was conducted using PubMed, Web of Science and Google scholar. Study selection was done independently by two reviewers and any discrepancy was resolved by third reviewer. A total of 23 articles were included after full-text reading. JBI checklist was used to assess the risk of bias for each study and RevMan 5.4 software was used to develop graphs. Discussion and conclusion: Ki-67, p53, cyclin-D1, E-Cadherin, vascular markers like α -SMA, mi-RNAs, chromosomal polysomy, and epigenetic modifications like gene methylations were the various biomarkers used in the included studies. Both Ki-67 and p53 were found to be the most commonly employed markers in field cancerisation. However Ki-67 has more confirmed role in identifying field changes and is an established independent prognostic indicator of loco-regional control and disease free- survival rate. Further prospective studies are needed to fully evaluate the role of these markers in predicting second events like loco-regional recurrences and second primaries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.