ArticleCureus2025
A Case of Primary Extragonadal Germ Cell Malignancy With Testicular Microlithiasis: Its Association and Significance.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Testicular microlithiasis and male fertility: a dual perspective integrating imaging and physiological insights.Reproductive biology and endocrinology : RB&E · 2025Pooled it
- From incidentaloma to actionable insight: a clinical-molecular-imaging framework for risk-stratified management of testicular microlithiasis.Frontiers in endocrinology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 30-year-old South Asian male with no specific medical history presented with shortness of breath of insidious onset for two months, with facial puffiness and progressive dysphagia. Physical examination revealed dilated veins over the upper chest, upper arms, and back, with an ejection systolic murmur. Thoracic imaging revealed a large mass occupying the anterior mediastinum, encasing the aorta with mass effect on the esophagus, and causing superior vena cava obstruction. Histopathological and immunohistochemical examination of the mass revealed a seminomatous germ cell tumor. Ultrasonography of the testes was normal except for microlithiasis. The patient was initiated on cisplatin-based chemotherapy and showed symptomatic improvement after two cycles. This case describes an uncommon presentation of primary extragonadal germ cell malignancy with testicular microlithiasis, a premalignant condition linked to gonadal germ cell malignancy. Further studies are needed to determine a correlation, if any, between testicular microlithiasis and extragonadal germ cell malignancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.