ArticleCureus2025
Intersecting Pathologies: Polycythemia Vera and Recurrent Infections in an Elderly Patient.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This case report highlights the diagnostic and therapeutic challenges encountered in the management of a 95-year-old female patient with polycythemia vera (PV) complicated by recurrent infections. The patient presented with significant leukocytosis, thrombocytosis, and concurrent infections, including a urinary tract infection and influenza B. PV, a myeloproliferative neoplasm, is characterized by increased production of red blood cells and often involves heightened activation of myeloid and megakaryocytic lineages, resulting in leukocytosis and thrombocytosis. These hematological abnormalities, coupled with underlying immune dysregulation, predispose patients to recurrent and severe infections. The patient's condition was further complicated by resistance to initial antibiotic therapy, necessitating adjustments in treatment. Despite resolving the infections, persistent leukocytosis raised concerns about the interplay between inflammatory, infectious, and neoplastic processes. This case underscores the complexities of managing patients with PV who exhibit overlapping hematological abnormalities and recurrent infections. It emphasizes the need for a multidisciplinary approach involving hematologists and infectious disease specialists to optimize care. The report also discusses the importance of preventive strategies, such as vaccinations, in reducing the risk of infections in high-risk populations, particularly those with myeloproliferative disorders.
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