ArticlePlastic and reconstructive surgery. Global open2025
Newly Identified Developmental Delays in a Large Population of Children With Nonsyndromic Cleft Lip and Palate.
Article in Plastic and reconstructive surgery. Global open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Neurodevelopmental disorders in children with cleft lip and palate: a systematic review.European child & adolescent psychiatry · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nonsyndromic cleft lip and/or palate (NSCLP) is the most common congenital craniofacial anomaly. Early recognition of developmental delays associated with NSCLP is critical for counseling and management. This study investigates developmental delays in a large population of children with NSCLP. Methods: This is an institutional review board-approved, retrospective analysis of children 5-21 years of age with a diagnosis of NSCLP. Demographic and clinical variables were collected for patients and a control group without NSCLP from the 2018 National Survey of Children's Health (NSCH) database. Results: A total of 617 patients with NSCLP subjects and 29,147 NSCH participants were included. Among orofacial clefts, 45.2% were unilateral cleft lip and palate, followed by isolated cleft palate (30%), bilateral cleft lip and palate (16.4%), and isolated cleft lip (8.4%). NSCLP children with isolated cleft lip (odds ratio [OR]: 3.97), unilateral cleft lip and palate (OR: 2.17) and bilateral cleft lip and palate (OR: 2.91) had significantly higher odds of being diagnosed with attention-deficit hyperactivity disorder than the NSCH cohort. Rates of autism/pervasive developmental disorder were higher in children with isolated cleft lip than cleft lip and palate (11.5% versus 4.7%, Conclusions: Higher rates of attention disorders and developmental delays in children with NSCLP highlight the importance of proper risk assessment and multidisciplinary management for this population.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.