Evidence map›Paper›PMID 40182131›Full record

ArticleOpen forum infectious diseases2025

Targeting Chronic Biofilm Infections With Patient-derived Phages: An In Vitro and Ex Vivo Proof-of-concept Study in Patients With Left Ventricular Assist Devices.

Melissa Pitton, Luca G Valente, Simone Oberhaensli, Bülent Gözel, Stephan M Jakob, Parham Sendi, Monika Fürholz, David R Cameron, Yok-Ai Que

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Evolution of Symbiosis inBiomolecules · 2026
    Review
  2. Infections in mechanical circulatory support.Frontiers in cardiovascular medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Melissa PittonDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Luca G ValenteDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-7927-9846
Simone OberhaensliInterfaculty Bioinformatics Unit, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-2116-1685
Bülent GözelDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-3519-0804
Stephan M JakobDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0009-0008-9878-0039
Parham SendiInstitute for Infectious Diseases, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-7347-6312
Monika FürholzDepartment of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
David R CameronDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-3700-5625
Yok-Ai QueDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0001-9443-6101

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Phage therapy is being reconsidered as a valuable approach to combat antimicrobial resistance. We recently established a personalized phage therapy pipeline in healthy volunteers, where therapeutic phages were isolated from individuals' skin microbiota. In this study, we aim to validate this pipeline in end-stage heart failure patients supported by left ventricular assist devices (LVADs), focusing on phages targeting Methods: Over a 2.5-year period, 45 LVAD patients were consistently sampled at their driveline exit sites and foreheads. Results: Conclusions: This study validated a personalized phage therapy approach, where phages from a patient's own microbiota can be used in chronic infection settings as therapeutic agents.

Indexed as

biofilms associated infectionsleft ventricular assist devicesmedical microbiologymultidrug resistant Staphylococcus epidermidispersonalized phage therapy

Identifiers

PMID40182131
PMCPMC11966103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.