ArticleFrontiers in oncology2025
Proton stereotactic centralized ablative radiation therapy for treating bulky tumor: a treatment plan study.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- C-X-C Motif Chemokine Receptor 4 (CXCR4)-Targeted Biologically Guided Proton Spatially Fractionated Radiotherapy for Bulky Limited-Stage Small Cell Lung Cancer.Precision radiation oncology · 2026Article
- A dosimetric study of photon energy and flattening filter mode combinations in Stereotactic Central Ablative Radiotherapy.Journal of applied clinical medical physics · 2026Article
- Stereotactic centralized ablative radiation therapy: a framework for ultra-heterogeneous radiotherapy of bulky tumors.Frontiers in oncology · 2026Article
- SCART sequential lattice spatial fractionated radiotherapy combined with chemotherapy for recurrent ovarian cancer with bulky bone metastasis: a case report.Frontiers in oncology · 2026Article
- Stereotactic core ablative radiation therapy for small hypoxic tumors: impact of dosimetric approaches and consequent optimization strategy in the context of spatially fractionated radiation therapy.Frontiers in oncology · 2025Article
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Abstract
Objective: Stereotactic centralized/core ablative radiation therapy (SCART) is a novel radiotherapy approach. This study investigates the potential benefits of proton-based SCART (pSCART) by leveraging the dosimetric advantages of protons and integrating them with the SCART technique. Methods: Five clinical cases previously treated with conventional proton therapy were selected for this study. The pSCART plans utilized a relative biological effectiveness (RBE) prescription dose of 24 Gy (RBE) × 3 fractions, with each plan consisting of three to five fields. The prescribed dose for the CyberKnife SCART was the highest value meeting the organs-at-risk (OARs) dose limits and the tumor edge dose limits. The dose distributions of the CyberKnife-based SCART and pSCART plans were compared using five criteria: i) prescription dose; ii) 80% prescription dose volume, targets coverage at 80% and 20% dose levels, and the 80%/20% ratio; iii) volume receiving >5 Gy outside the tumor edge; iv) dose tolerance limits to OARs; and v) mean dose to OARs. Results: pSCART can deliver a higher prescription dose of 24 Gy × 3 fractions versus SCART's 15 Gy × 2-3 fractions or 18 Gy × 2 fractions. Specifically, pSCART outperforms SCART in terms of the 80% prescription dose volume and 80% dose level coverage of stereotactic centralized/core target volumes (SCTV) achieving 69.77%-100.00% versus SCART's 43.6%-99.5%. The 20% dose level coverage for gross target volume (GTV) is slightly lower for pSCART, achieving 88.96%-98.64% versus SCART's 90.1%-99.9%. The maximum point dose outside the target volume is lower for pSCART at 4.58-6.19 Gy versus SCART's 4.78-6.67 Gy; additionally, the V Conclusions: This work provides initial insights into evaluating treatment plans for bulky tumors using pSCART. Compared to the CyberKnife SCART, pSCART generates significantly higher prescription doses and larger high-dose regions within the GTV while delivering lower doses at the tumor edge, enhancing normal tissue sparing.
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