Evidence map›Paper›PMID 40182023›Full record

ArticleEnvironmental epigenetics2025

Non-genotoxic carcinogens (TPA and mezerein) activate tumourous transformation through miR let-7-mediated Hmga2 expression in Bhas42 cells.

Moon Yi Ko, Euijun Min, Minjeong Kim, Heejin Park, Sumi Jang, Younhee Kim, Byoung-Seok Lee, Sung-Ae Hyun, Minhan Ka

Abstract read
In one paragraph

Article in Environmental epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Moon Yi KoDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.
Euijun MinDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.
Minjeong KimDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.
Heejin ParkDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.
Sumi JangDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.
Younhee KimDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.ORCID https://orcid.org/0000-0001-7647-9175
Byoung-Seok LeeDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.
Sung-Ae HyunDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.
Minhan KaDepartment of Advanced Toxicology Research, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.ORCID https://orcid.org/0000-0003-2336-4184

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A Bhas42 cell transformation assay is a method used to detect the tumour-promoting activities of chemicals. However, the mechanisms underlying tumour transformations mediated by non-genotoxic carcinogens (NGCs) are poorly understood. This study aimed to examine the correlation between 12-

Indexed as

Ezh2Hmga2mezereinmiR let-7non-genotoxic carcinogensTPA

Identifiers

PMID40182023
PMCPMC11967402

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.