Evidence map›Paper›PMID 40181954›Full record

ArticleFrontiers in immunology2025

Expression and significance of lncRNAs derived from PBMC in rheumatoid arthritis.

Xiaoke Yang, Zhongling Yang, Ziqiang Shuai, Mingming Zhang, Sheng-Qian Xu, Zong Wen Shuai

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoke Yang *Department of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Zhongling Yang *Department of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Ziqiang Shuai *Department of Sports Injury and Arthroscopic Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Mingming ZhangDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Sheng-Qian XuDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Zong Wen ShuaiDepartment of Rheumatology and Immunology, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Long non-coding RNAs (lncRNAs) are gaining recognition for their critical involvement in diverse autoimmune disorders. Nevertheless, reseach investigating the role of lncRNAs in rheumatoid arthritis (RA) is relatively scarce. Methods: Comprehensive transcriptome sequencing was executed to acquire a lncRNA expression pattern in peripheral blood mononuclear cells (PBMC) of RA. Then, we confirmed the sequencing data by real-time quantitative polymerase chain reaction (RT-qPCR). Results: The findings showed decreased levels of LINC00494, TSP0AP1-AS1, MCM3AP-AS1 and LINC01588, increased levels of OIP5-AS1, in PBMC of RA compared to controls. ROC analysis for the five dysregulated lncRNAs demonstrated an area under curve (AUC) extending from 0.654 to 0.915, and their combination had high utility for accurate RA diagnosis (AUC = 0.920). There existed a negative relation between RF and LINC00494 expression ( Conclusions: Our study indicated that LINC00494, TSP0AP1-AS1, MCM3AP-AS1, LINC01588 and OIP5-AS1 in PBMC may be the biomarkers for RA.

Indexed as

Arthritis, RheumatoidLeukocytes, MononuclearRNA, Long NoncodingAdultAgedBiomarkersFemaleGene Expression ProfilingGene Expression RegulationHumansMaleMiddle AgedROC CurveTranscriptomeBiomarkersRNA, Long Noncodingbiomarkerlong non-coding RNApathogenesisPBMCrheumatoid arthritis

Identifiers

PMID40181954
PMCPMC11965121

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.