ArticleFrontiers in nutrition2025
Effects of dietary oxidative balance score on diabetic nephropathy and renal function: insights from retrospective and cross-sectional studies.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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10 authors.
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Abstract
Background: The relationship between dietary oxidative balance score (DOBS) and diabetes-related renal events remains unclear. Methods: In this study, the associations between serum micronutrients and diabetic nephropathy (DN) in participants matched by propensity score (PSM) were retrospectively analyzed. And next, a cross-sectional analysis was performed with the National Health and Nutritional Examination Survey (NHANES) database. Weighted multivariate adjusted logistic regression models, dose-response curves, subgroup analysis, and mediation analysis were the main methods of this study. Finally, sensitivity analyses were performed by PSM and multiple imputation (MI). Results: Retrospective findings suggest that single antioxidants may not be representative of an individual's overall antioxidant levels. The results of the cross-sectional study indicated that the higher the DOBS, the greater the beneficial effects on DN [Q4 vs. Q1: OR (95% CI): 0.78 (0.63, 0.96), Conclusion: Higher dietary antioxidant exposure has a positive effect on DN and renal function in DN, mediated partially by chronic inflammation.
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