ArticleCirculation2025
Genetic and Lifestyle Risks for Coronary Artery Disease and Long-Term Risk of Incident Dementia Subtypes.
Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Associations of long-term exposure to source-specific PMEuropean archives of psychiatry and clinical neuroscience · 2026Article
- Impact of risk factor burden and vascular bed involvement on dementia risk in individuals with established cardiovascular disease.American journal of preventive cardiology · 2026Article
- Genetic evidence supports the combined targeting of lipoprotein(a) and LDL cholesterol to reduce coronary artery disease risk.Nature cardiovascular research · 2026Article
- Interactions between minimal amount of exercise and low-density lipoprotein cholesterol on incident dementia after stroke.iScience · 2026Article
- Modifying genetic susceptibility to coronary heart disease through an integrated plant-based diet-lifestyle.The Lancet regional health. Europe · 2026Article
- The enigma of vascular dementia: current state and emerging perspectives.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Advances in brain MRI for CAD-associated cognitive impairment with supplementary perspectives from traditional Chinese medicine.Frontiers in medicine · 2026Review
- Heterogeneous cognitive and neuroimaging profiles in older adults with type 2 diabetes: the modifying effect of coronary artery disease.Frontiers in aging neuroscience · 2026Article
- Cardiovascular-kidney-metabolic health, genetic susceptibility, and the risk of dementia: A prospective cohort study.The journal of prevention of Alzheimer's disease · 2026Article
- Sarcopenia index is a superior prognostic marker to creatinine-cystatin C ratio in older adults with hip fracture.Journal of orthopaedic surgery and research · 2025Article
- Latent Profiles Based on Combined Risk Factors for Cognitive Decline in European Older Adults: A Retrospective Study Based on the SHARE HCAP Project.Neurology international · 2025Article
- MEDICATION EXPOSURE AND NEURODEGENERATIVE DISEASE RISK ACROSS NATIONAL BIOBANKS.medRxiv : the preprint server for health sciences · 2025Article
- The heart-brain axis: unraveling the interconnections between cardiovascular and Alzheimer's diseases.Frontiers in cardiovascular medicine · 2025Review
- Moderate tea consumption and dementia-related neuroimaging markers.Frontiers in neurology · 2025Article
- Association between the dietary index for gut microbiota and Alzheimer's disease: A cross-sectional study from the National Health and Nutrition Examination Survey (2004 to 2018).Alzheimer's & dementia (Amsterdam, Netherlands)Article
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3 authors.
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Abstract
backgroundShared genetic and lifestyle risk factors may underlie the development of both coronary artery disease (CAD) and dementia. We examined whether an increased genetic risk for CAD is associated with long-term risk of developing all-cause, Alzheimer's, or vascular dementia, and investigated whether differences in potentially modifiable lifestyle factors in the mid- to late-life period may attenuate this risk.
methodsA prospective cohort study of 365 782 participants free from dementia for at least 5 years after baseline assessment was conducted within the UK Biobank cohort. Genetic risk was assessed using a genomewide polygenic risk score (PRS) for CAD and lifestyle risk using a modified version of the American Heart Association's Life's Essential 8 Lifestyle Risk Score (LRS). Higher values for both scores were deemed to represent increased risk. Primary outcomes were incident all-cause, Alzheimer's, and vascular dementia diagnoses obtained from self-report and electronic health records. Secondary outcomes were neuroimaging phenotypes measured in 32 028 participants recalled for magnetic resonance imaging. Sensitivity analyses were conducted to test the extent by which biological and behavioral risk factors contributed to observed associations.
resultsA total of 8870 cases of all-cause dementia were observed over a median 13.9-year follow-up. Both genetic (PRS) and lifestyle (LRS) risk scores for CAD were associated with a modestly elevated risk of all-cause dementia (subhazard ratio per SD increase, 1.10 [1.08, 1.12],
conclusionsIndividuals who are genetically predisposed to developing CAD also face an increased risk of developing dementia in old age. This risk is reduced in those demonstrating healthy lifestyle profiles earlier in the lifespan, particularly in those who may be at an increased risk of developing dementia caused by an underlying vascular pathology.
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