Evidence map›Paper›PMID 40181740›Full record

ArticleCancer research and treatment2026

The Effect of Alcohol Consumption Behavior Changes on Gastric Cancer Risks Stratified by Sex in South Korea.

Yonghoon Choi, Jieun Jang, Hyeong Ho Jo, Nayoung Kim

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Article in Cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Yonghoon ChoiDepartment of Internal Medicine and Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Jieun JangDivision of Clinical Research, Research Institute, National Cancer Center, Goyang, Korea.
Hyeong Ho JoDepartment of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.
Nayoung KimDepartment of Internal Medicine and Research Center for Sex- and Gender-Specific Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Funding

Ministry of Science and ICTNational Research Foundation of Korea RS 2024-00337453Seoul National University Bundang Hospital 02-2023-0012
6 · The paper itself

Abstract

purposeThe effect of behavior changes in alcohol drinking on gastric cancer (GC) development, and the sex differences in those effects have not yet been fully elucidated. This study investigated the effect of behavior changes in alcohol drinking on the GC risk by sex. MATERIALS AND

methodsThe cohort consisted of 310,192 Koreans (≥ 40 years) from the National Health Insurance Service-Health Screening Cohort with a median follow-up period of 12 years. Subjects were classified according to alcohol consumption behavior changes (non-drinker, quitter, reducer, sustainer, and increaser). The independent effect of changes in alcohol drinking patterns or concurrent effect of alcohol on GC risk were evaluated using the Cox proportional hazard regression.

resultsIn males, non-drinkers showed a lower risk of developing GC (hazard ratio [HR], 0.91; 95% confidence interval [CI], 0.84 to 0.98), whereas increasers showed a higher risk of GC than sustainers (HR, 1.11; 95% CI, 1.02 to 1.20). Starting to drink alcohol, even at a mild level, was associated with an increased GC risk, while a decreased GC risk was induced when alcohol consumption dose decreases to a mild from a moderate level among males. However, in females, only substantial change of alcohol consumption dose from non- to heavy-drinking was associated with increased GC risk (HR, 1.97; 95% CI, 0.98 to 3.96).

conclusionThese results suggest that alcohol abstinence can reduce the risk of developing GC, particularly among males.

Indexed as

Alcohol DrinkingStomach NeoplasmsAdultAgedCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedProportional Hazards ModelsRepublic of KoreaRisk FactorsSex FactorsAlcohol abstinencePrimary preventionSex characteristicsStomach neoplasms

Identifiers

PMID40181740
PMCPMC12800938

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