Evidence map›Paper›PMID 40181653›Full record

ArticleEpigenetics2025

A qualitative prognostic biomarker for melanoma based on the relative methylation orderings of CpG loci.

Yue Huo, Yaru Gao, Jiayi Ruan, Lingli Wang, Hongdong Li, Guini Hong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yue HuoSchool of Public Health and Health Management, Gannan Medical University, Ganzhou, China.
Yaru GaoSchool of Public Health and Health Management, Gannan Medical University, Ganzhou, China.
Jiayi RuanSchool of Medical Information Engineering, Gannan Medical University, Ganzhou, China.
Lingli WangSchool of Medical Information Engineering, Gannan Medical University, Ganzhou, China.
Hongdong LiSchool of Medical Information Engineering, Gannan Medical University, Ganzhou, China.
Guini HongSchool of Medical Information Engineering, Gannan Medical University, Ganzhou, China.ORCID 0000-0002-0277-6123

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin cutaneous melanoma (SKCM) is an aggressive tumor with a poor prognosis. We developed SKCM-P8, a novel qualitative prognostic biomarker based on the relative methylation orderings of eight pairs of loci. Analysis of a training cohort and two independent validation datasets revealed a significant difference in overall survival between high- and low-risk groups stratified by SKCM-P8 (

Indexed as

Biomarkers, TumorCpG IslandsDNA MethylationMelanomaSkin NeoplasmsCutaneous Malignant MelanomaFemaleHumansMaleMiddle AgedPrognosisBiomarkers, TumorMelanomaprognosisrelative methylation orderings

Identifiers

PMID40181653
PMCPMC11980477

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.