ArticleThe Journal of physiology2026
Ketogenic diet and ketone salts differentially improve cardiometabolic complications in an HFpEF rat model.
Article in The Journal of physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The keto cure? Exploring ketogenic diet in heart failure with preserved ejection fraction.The Journal of physiology · 2026Article
- Cardiac regulatory mechanisms: Translating fundamental discoveries into novel therapeutics.The Journal of physiology · 2026Article
- Metabolic and gut microbiota effects of ketogenic diet and exogenous ketone salts in a rat model of metabolic syndrome.European journal of nutrition · 2026Article
- Nursing Care of Heart Failure With Preserved Ejection Fraction: Review.Reviews in cardiovascular medicine · 2026Review
- A narrative review of dietary patterns in cardiovascular-kidney-metabolic syndrome.Frontiers in nutrition · 2026Review
- Potential causes and significance of elevated blood ketone levels in patients with heart failure with preserved ejection fraction.Frontiers in nutrition · 2025Article
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Authors and funding
18 authors.
Funding
Abstract
Heart failure with preserved ejection fraction (HFpEF) remains a major health concern with limited therapeutic options. Growing evidence supports the multiple benefits of ketones in heart disease, but their impact on HFpEF remains unknown. We investigated whether increasing ketones can help to manage HFpEF. Using the ZSF1 rat model of HFpEF, 16-week-old rats were randomly assigned to one of three subgroups: (i) control diet; (ii) ketogenic diet (KD); or (iii) control diet with added exogenous ketone salts (KS) in their drinking water for 10 weeks. We found that both KD and KS ameliorated the HFpEF phenotype by improving structural echocardiographic parameters, lowering glycaemia and lipid profiles, and reducing HFpEF-related fibrosis and hypertrophy without impacting in vivo diastolic function. Nevertheless, ex vivo cardiomyocyte preparations showed improved calcium handling and myofilament relaxation, suggesting benefits at the cellular level. Interestingly, KD still proved effective, despite the potentially adverse increase in fat mass. There was decreased myofilament Ca
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