Evidence map›Paper›PMID 40181441›Full record

ArticlePilot and feasibility studies2025

Four-week Nordic hamstring exercise intervention for individuals with ACL reconstruction via hamstrings tendon autograft: feasibility of a pilot randomized controlled trial.

Grant E Norte, Neal R Glaviano, David A Sherman, Justin L Rush, Amanda M Murray

Registry-linked trialAbstract read
In one paragraph

Article in Pilot and feasibility studies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05738200 (Use of Nordic Hamstring Exercise to Improve Hamstrings Function in Patients After ACL Reconstruction), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05738200 nacompletednot on this map

Use of Nordic Hamstring Exercise to Improve Hamstrings Function in Patients After ACL Reconstruction

TypeinterventionalSponsorUniversity of ToledoRan2018 to 2022Enrolled23ConditionsACL Injury, Muscle Weakness, Neuromuscular ManifestationsArmsNordic Hamstring Exercise
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Grant E NorteCognition, Neuroplasticity, & Sarcopenia (CNS) Laboratory, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, FL, USA. grant.norte@ucf.edu.ORCID http://orcid.org/0000-0001-8052-3642
Neal R GlavianoDepartment of Kinesiology, University of Connecticut, Storrs, CT, USA.
David A ShermanMovement Neuroscience Laboratory, Northeastern University, Boston, MA, USA.
Justin L RushDivision of Physical Therapy, School of Rehabilitation Sciences, Ohio University, Athens, OH, USA.
Amanda M MurrayDepartment of Kinesiology, University of Connecticut, Storrs, CT, USA.

Funding

American College of Sports Medicine 18-00731
6 · The paper itself

Abstract

backgroundThe Nordic hamstring exercise (NHE) has been widely used among uninjured, athletic populations to mitigate the risk of hamstring injury, yet little is known about its utility as an intervention for individuals who undergo ACL reconstruction with hamstring tendon autograft (ACLR-HT). Understanding the feasibility of NHE as a means of enhancing hamstring function may aid in the development of evidence-based recommendations to guide hamstring recovery. Our aim was to determine the feasibility of conducting a pilot NHE trial among individuals with ACLR-HT.

methodsWe used a single-blind randomized controlled trial with parallel arms to investigate individuals 18-35 years with primary, unilateral ACLR-HT. Twenty-three participants were randomized to a standardized, 4-week (10 session) progressive NHE intervention (n = 17) or usual care control (n = 6) group at a 3:1 ratio. Those randomized to the control group were eligible to open-enroll in the intervention group at the completion of the original study period. Primary feasibility outcomes included recruitment uptake, protocol adherence, dose goal attainment, and retention. Exercise perceptions and safety were also assessed. Summary statistics were used to descriptively report all findings.

resultsTwo control participants were open-enrolled in the intervention group after completing their original study period (n = 19). All participants (88.5% recruitment uptake) adhered to the exercise protocol (100%) and 18 participants (94.7%) attained the total exercise dosage goal. A 100% retention rate was observed, as all participants (intervention 17 randomized, 2 open-enrolled; control 6) returned for their follow-up assessment.

conclusionsA standardized, 4-week progressive NHE protocol is feasible for individuals with ACLR-HT. Positive perceptions of exercise, minimal exercise-related discomfort, and no reported adverse events further support the acceptability of this protocol and the likelihood of successful implementation in future efficacy trials.

trial registrationClinicalTrials.gov, NCT05738200. Registered 2 November 2022-retrospectively registered, https://clinicaltrials.gov/study/NCT05738200 .

Indexed as

Clinical trialEccentric exerciseSemitendinosus

Identifiers

PMID40181441
PMCPMC11969947

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.