Evidence map›Paper›PMID 40181397›Full record

ArticleAnnals of general psychiatry2025

The independent role of fine particulate matter and genetic liability on cognition in older adults.

Shu-Fen Liao, Ta-Chien Chan, Mei-Hsin Su, Mei-Chen Lin, Chi-Shin Wu, Chun-Chieh Fan, Shi-Heng Wang

Abstract read
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In one paragraph

Article in Annals of general psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Shu-Fen LiaoDepartment of Medical Research, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Ta-Chien ChanResearch Center for Humanities and Social Sciences, Academia Sinica, Taipei, Taiwan.
Mei-Hsin SuDepartment of Public Health, College of Public Health, China Medical University, Taichung, Taiwan.
Mei-Chen LinNational Center for Geriatrics and Welfare Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Miaoli, Taiwan.
Chi-Shin WuNational Center for Geriatrics and Welfare Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Miaoli, Taiwan.
Chun-Chieh FanCenter for Population Neuroscience and Genetics, Laureate Institute for Brain Research, Tulsa, OK, USA.
Shi-Heng WangNational Center for Geriatrics and Welfare Research, National Health Research Institutes, 35, Keyan Road, Zhunan Town, Miaoli County 350, Miaoli, Taiwan. shwang@nhri.edu.tw.

Funding

National Health Research Institutes CG-112-GP-10, CG-113-GP-10, NHRI-EX109-10931PI, NHRI-EX110-10931PI, NHRI-EX111-10931PITaipei Medical University TMU112-AE1-B14Wan Fang Hospital 112-wf-eva-16, 113-wf-eva-07
6 · The paper itself

Abstract

backgroundGenetic susceptibility to mental health and cognitive traits, as well as air pollution, significantly impact cognition. The interplay between polygenic liability and fine particulate matter (PM

methodsPolygenic risk score (PRS) for cognitive performance (CP PRS), Alzheimer's disease (AD PRS), schizophrenia (SCZ PRS), and major depression (MDD PRS) were computed representing genetic susceptibility for an individual. APOE genotype was classified into E3/E3, E3/E4, and E4/E4. The five-year average concentration of PM

resultsOur analyses included 25,593 participants from 164 townships. Participants exposed to higher PM

conclusionsHuman polygenic loading and PM

Indexed as

Air pollutionAlzheimer’s diseaseMajor depressionPM2.5Polygenic risk scoreSchizophreniaTaiwan biobank

Identifiers

PMID40181397
PMCPMC11969746

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