ArticleAIDS research and therapy2025
Serological status of measles, mumps, and rubella antibodies in HIV-positive women of childbearing age at a referral hospital in Iran.
Article in AIDS research and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe human immunodeficiency virus (HIV) increases susceptibility to measles, mumps, and rubella (MMR) infections due to decreased cluster of differentiation 4 + T-cell levels and rapid waning of protective antibodies following vaccination, which imposes a significant impact on HIV-positive women of reproductive age, for whom MMR vaccination is a crucial preventive measure. This study aimed to shed light on the immunity status of women of childbearing age with HIV infection post-MMR-vaccination during their childhood and the necessity of further vaccination in these individuals.
methodsTo evaluate seroconversion rates following vaccination through Iran's NIP or previous infection by assessing MMR IgG levels, all Iranian women aged 18-45 years referred to our voluntary counseling center, with or without HIV infection and CD4 levels 200 cells/mm
resultsIn this study, 150 women participated, with a mean age (± SD) of 36.49 (± 6.80). Mean rubella and measles IgG levels of HIV-positive participants (95.08 ± 79.42 IU/Ml) were higher than HIV-negative peers (8.98 ± 3.83 mg/dL) with no significant associations (p-value > 0.05). However, mumps IgG levels were significantly lower compared to HIV-negative participants (9.87 ± 28.70 mg/dL, p-value < 0.001). Additionally, HIV-positive participants significantly exhibited lower total immunity (n = 73, 97.3) compared to HIV-negative participants (n = 64, 85.3) (p-value = 0.07). HIV-positive individuals who did not have seroimmunity against mumps infection had significantly lower CD4 NADIR counts (cells/mm3) (mean ± SD = 259.00 ± 203.31, p-value: 0.025). Moreover, regression analyses demonstrated significant associations between decreased mumps IgG levels and lower CD4 NADIR counts (AOR = 1.004, 95% CI = 1-1.008, p value = 0.03).
conclusionOur research found that HIV-positive women may need MMR revaccination due to increased susceptibility to at least one of these viruses. We also highlighted the significance of considering lower CD4 NADIR as a risk factor for mumps development in women living with HIV infection.
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