SynthesisBMC oral health2025
Does intra-articular injection of PRP help patients with temporomandibular joint osteoarthritis after joint puncture? a systematic review and meta-analysis of randomized controlled trials.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preliminary Evidence on Intra-Articular Autologous Conditioned Serum (ACS) in Temporomandibular Joint Disorders (TMDs): A Systematic Review with a Focus on Mechanisms and Potential Application in Clinical Practice.International journal of molecular sciences · 2025Pooled it
- Platelet-rich plasma versus hyaluronic acid injection following arthrocentesis for temporomandibular joint disorders under sedation: a comparative clinical study.Oral and maxillofacial surgery · 2026Trial
- Standalone Intra-Articular Injections for Temporomandibular Joint Disorders: Overview of Meta-Analytic Evidence.Journal of clinical medicine · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveThe aim of this study is to conduct a systematic review to evaluate whether intra-articular injection of platelet-rich plasma (PRP) after joint puncture can aid in the recovery of patients with temporomandibular joint osteoarthritis (TMJOA).
methodsWe searched PubMed, Cochrane Library, Embase and Web of Science as of March 3, 2024. Retrieved a total of 392 articles. We included all published randomized controlled trials (RCTs). All RCTs, including studies on PRP injection after joint puncture in patients with TMJOA. The primary outcome was pain reduction, and the secondary outcome was the improvement of maximal mouth opening (MMO) and joint sounds. All outcome measures were analyzed by calculating the standardized mean differences (SMDs) and 95% confidence intervals (CIs).
resultsA total of 392 articles were retrieved, and ultimately, 6 articles met the inclusion criteria. The study involved 199 TMJOA patients. The results indicated that compared to the control group, PRP injection after joint puncture showed significant improvements in alleviating pain (SMD =-0.99; 95% CI =-1.35 ~-0.63; P <0.00001, I
conclusionsCompared to joint puncture alone, the intra-articular injection of PRP after joint puncture was more effective in relieving pain. At 1-month and 6-month follow-ups, patients in the PRP group showed significant improvements in MMO compared to the control group. However, after 12 months of follow-up, limited evidence indicated significant improvements in MMO and joint sounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.