Evidence map›Paper›PMID 40181309›Full record

ArticleBMC pregnancy and childbirth2025

Association between antepartum depressive symptoms and prenatal care utilization and milestones: a retrospective cohort study.

Minyoung Jang, Malini Ramaiyer, Sarah Olson, Kristin Voegtline, Cybill Esguerra

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Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Minyoung JangDepartment of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, USA.
Malini RamaiyerDepartment of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, USA.
Sarah OlsonBiostatistics, Epidemiology, and Data Management Core, Johns Hopkins University, Baltimore, MD, USA.
Kristin VoegtlineDivision of General Pediatrics, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Cybill EsguerraDepartment of Obstetrics and Gynecology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, USA. cesguer1@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the relationship between antepartum depressive symptoms and prenatal care utilization and completion of prenatal care milestones, namely, routine screening tests and vaccinations in pregnancy.

methodsThis retrospective cohort includes pregnant individuals who completed first or second trimester screening using the Edinburgh Postnatal Depression Scale (EPDS) between 2020 and 2021. Baseline characteristics were compared between individuals who screened positive versus negative for depression. Multivariable logistic regression models were used to estimate odds of completing third trimester prenatal care milestones, including sexually transmitted infection screening, glucose tolerance testing, group B streptococcus testing, and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination.

resultsOf 718 individuals who completed the EPDS in early pregnancy, 85 (11.8%) screened positive for depressive symptoms. A greater proportion of these individuals were younger (median age 28 vs. 31 years, P =.034), unpartnered (P =.005), publicly insured (P =.013), had a history of substance use (P <.001) or prior psychiatric diagnosis (P <.001), and entered prenatal care at later gestational ages (median 12.3 vs. 10.7 weeks, P =.002) than those who screened negative. Although there were no significant differences in total prenatal care visits attended between groups (P =.123), the adjusted odds of completing third trimester milestones including glucose tolerance testing (OR [95% CI] 0.60 [0.36-0.98]) and group B streptococcus testing (OR 0.56 [0.33-0.95]) were lower among individuals who screened positive for depressive symptoms. Less than half of individuals at risk for depression who were referred to mental health services successfully completed consultations during pregnancy.

conclusionsPregnant individuals who screen positive for depressive symptoms in early pregnancy comprised a socially vulnerable group at risk of missing third trimester prenatal care milestones. Mental health screening and integrated interventions across the perinatal continuum may help mitigate the current treatment gap for patients in need of mental health services during pregnancy.

Indexed as

DepressionPatient Acceptance of Health CarePregnancy ComplicationsPrenatal CareAdultFemaleHumansPregnancyRetrospective StudiesVaccinationYoung AdultDepressionGlucose tolerance testingGroup B streptococcus testingMental healthPrenatal care

Identifiers

PMID40181309
PMCPMC11969695

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