Evidence map›Paper›PMID 40181295›Full record

ArticleBMC pediatrics2025

Clinical characteristics, and outcomes of severe neonatal thrombocytopenia: a retrospective cohort study in China.

Yuanyuan Shan, Ting Peng, Peng Zhang, Guoqiang Cheng

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PubMed Full text at PMC Publisher
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Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Yuanyuan Shan *Department of Pediatric Intensive Care Unit, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Ting Peng *Department of Neonatology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Peng ZhangDepartment of Neonatology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China.
Guoqiang ChengDepartment of Neonatology, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. gqcheng_cm@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere neonatal thrombocytopenia, as a rare but life-threatening disease with multiple etiologies, has limited relevant reports in China. The single-center study was performed in a severe thrombocytopenic cohort to improve the prognosis of this disease.

methodsWe included all the patients diagnosed with severe thrombocytopenia (platelet counts ≤ 50 × 10

resultsAmong the 5819 inpatients, 194 with severe thrombocytopenia were included in this study, with 64.4% of the cases manifesting thrombocytopenia within 72 h of life. The highest incidence was recorded among extremely low birth weight neonates (6.5%). The main etiologies included sepsis (22.2%), genetic syndromes (14.4%), perinatal asphyxia (9.8%), necrotizing enterocolitis (NEC; 8.8%), and cytomegalovirus infection (6.7%). The median platelet nadir was 5.0 × 10

conclusionsSepsis, genetic syndromes, and perinatal asphyxia are the predominant etiologies of severe neonatal thrombocytopenia in China. The overall prognosis of severe neonatal thrombocytopenia is poor, but its severity and outcome were related to laboratory results (PT, APTT, and lactate) and the underlying etiology.

Indexed as

ThrombocytopeniaThrombocytopenia, Neonatal AlloimmuneChinaFemaleHumansIncidenceInfant, NewbornMalePlatelet CountPrognosisRetrospective StudiesSeverity of Illness IndexHemorrhageNeonatesPlatelet transfusionThrombocytopenia

Identifiers

PMID40181295
PMCPMC11969917

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