ArticleBMC cancer2025
Clinicopathologic characteristics and prognostic factors of pure gastric neuroendocrine carcinoma patients undergoing radical surgery.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Neuroendocrine neoplasms of the stomach. Update on diagnostic criteria, classification, and prognostic markers.Virchows Archiv : an international journal of pathology · 2026Review
- Differences in Endoscopic Features of Gastric Neuroendocrine Tumor and Neuroendocrine Carcinoma From a Clinicopathological Perspective.JGH open : an open access journal of gastroenterology and hepatology · 2025Review
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12 authors.
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Abstract
backgroundThere is a low incidence of gastric neuroendocrine carcinoma (G-NEC), but it is associated with particularly aggressive biological behaviours and poor prognosis compared with other gastric neoplasms. Our study aimed to investigate the clinicopathologic traits and prognostic factors of patients with pure gastric neuroendocrine carcinoma treated with radical surgery.
methodsWe retrospectively analysed 60 patients with pure G-NEC who underwent radical gastrectomy between March 2010 and May 2019. 68 patient who underwent curative surgery for mixed gastric adenoneuroendocrine carcinoma (G-ANEC) from August 2012 to June 2022. The relationships between the clinicopathologic characteristics of pure G-NEC and overall survival (OS) and disease-free survival (DFS), as well as the comparison of pure-NEC with G-ANEC in terms of prognosis and treatment regimens, were evaluated using the Kaplan-Meier method and (or) Cox regression.
resultsThe gastroesophageal junction (GEJ) was the predilection site for G-NEC. Tumor location, histology, and lymph node metastasis status were independent prognostic factors for OS (P < 0.05). Pathological T stage and the presence or absence of lymph node metastasis were independently associated variables with DFS (P = 0.019 and P = 0.041). Large cell neuroendocrine carcinoma (LCGNEC) did not differ statistically from the small cell neuroendocrine carcinoma (SCGNEC) (P = 0.314) for OS, while mixed type (MGNEC) vs. LCGNEC did differ significantly (P = 0.031). There were no significant differences in OS and DFS between etoposide and cisplatin (EP) and S-1 + oxaliplatin (SOX) / oxaliplatin + capecitabine (XELOX). The study of 106 patients found no significant impact of NEC proportion on OS (P = 0.438) or DFS (P = 0.079). Neoadjuvant/adjuvant chemotherapy targeting NEC versus adenocarcinoma showed no statistical difference in OS (P = 0.415, P = 0.350), but there was a trend toward longer survival with NEC-targeted regimen.
conclusionsThe LCGNEC did not differ statistically from the SCGNEC for OS, while the MGNEC vs. LCGNEC were different. The prognosis of G-NEC was related to the tumor location, histology, postoperative T stage, and lymph node metastasis. For gastric neuroendocrine carcinoma, prognosis does not differ statistically by NEC proportion. Chemotherapy regimens targeting lymph node metastases with an NEC component maybe better prognosis than those focusing on the adenocarcinoma component.
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