ArticleMolecular psychiatry2025
A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations.
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Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6citing papers in PubMed
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Who cites it
6 citing papers in PubMed.
- Optical mapping reveals a higher level of large-scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease.The Journal of pathology · 2026Article
- Association ofGenes · 2026Article
- Gene-by-Sleep Duration Interaction for Glycemic Traits in over 480,000 Individuals.medRxiv : the preprint server for health sciences · 2026Article
- Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals.medRxiv : the preprint server for health sciences · 2025Article
- Robust Mixed Model Association Test for Gene-Environment Interactions.medRxiv : the preprint server for health sciences · 2025Article
- Self-reported sleep disturbances are associated with osteoporosis: multivariable-adjusted and Mendelian randomization analyses in UK Biobank.JBMR plus · 2025Article
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Authors and funding
163 authors.
Pavithra Nagarajan *Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-0036-9970
Thomas W Winkler *Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.ORCID 0000-0003-0292-5421
Amy R Bentley *Center for Research on Genomics and Global Health, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0827-9101
Clint L Miller *Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Aldi T Kraja *University of Mississippi Medical Center, Jackson, MS, USA.
Karen Schwander *Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Songmi LeeBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Wenyi WangDepartment of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.
Michael R BrownHuman Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.ORCID 0000-0002-5235-9037
John L MorrisonDivision of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Ayush GiriDivision of Quantitative and Clinical Sciences, Department of Obstetrics & Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA.
Jeffrey R O'ConnellDivision of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Traci M BartzCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Lisa de Las FuentesCardiovascular Division, Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-4689-325X
Valborg GudmundsdottirIcelandic Heart Association, Kopavogur, Iceland.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0002-5264-5068
Sarah E HarrisDepartment of Psychology, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-4941-5106
Zhijie HuangDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Mart KalsEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Minjung KhoGraduate School of Data Science, Seoul National University, Seoul, South Korea.
Christophe LefevreDepartment of Data Sciences, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.ORCID 0000-0002-2876-0648
Jian'an LuanMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-3137-6337
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID 0000-0002-7200-5455
Massimo ManginoDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0002-2167-7470
Yuri MilaneschiDepartment of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, Netherlands.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0001-8883-2511
Varun RaoDivision of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Rainer RauramaaKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Botong ShenLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Stefan StadlerDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.ORCID 0000-0002-8783-618X
Quan SunDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-8324-2803
Jingxian TangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Sébastien ThériaultDepartment of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Quebec City, QC, Canada.
Adriaan van der GraafStatistical Genetics Group, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.ORCID 0000-0001-8450-3518
Yujie WangDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Stefan WeissDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-3553-4315
Kenneth E WestermanDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Qian YangMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Tabara YasuharuGraduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.
Wei ZhaoSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-7388-0692
Wanying ZhuDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Drew AltschulDepartment of Psychology, The University of Edinburgh, Edinburgh, UK.
Md Abu Yusuf AnsariDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
Pramod AnuguJackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
Anna D Argoty-PantojaDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Michael ArztDepartment of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Hugues AschardDepartment of Computational Biology, F-75015 Paris, France Institut Pasteur, Université Paris Cité, Paris, France.
John R AttiaSchool of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia.ORCID 0000-0001-9800-1308
Lydia BazzannoDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Max A BreyerDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Jennifer A BrodyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Brian E CadeDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-1424-0673
Hung-Hsin ChenDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-1921-2797
Yii-Der Ida ChenThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Zekai ChenDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.ORCID 0000-0003-0964-0111
Latchezar M DimitrovDepartment of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Anh DoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Jiawen DuDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-3711-8101
Charles T DupontDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0009-0000-7134-0908
Todd L EdwardsBiomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs, Nashville, TN, USA.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Tariq FaquihDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Stephan B FelixDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
Susan P Fisher-HochSchool of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA.
James S FloydCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Mariaelisa GraffDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0001-6380-1735
Charles GuCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-8527-8145
Dongfeng GuShenzhen Key Laboratory of Cardiovascular Health and Precision Medicine, Southern University of Science and Technology, Shenzhen, China.
Kristen G HairstonDepartment of Endocrinology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Anthony J HanleyDepartment of Nutritional Sciences, University of Toronto, Toronto, ON, Canada.
Iris M HeidDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.ORCID 0000-0002-4122-5308
Sami HeikkinenInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-6083-2402
Heather M HighlandDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-3583-8239
Michelle M HoodDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-1049-8426
Mika KähönenDepartment of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere, Finland.
Carrie A Karvonen-GutierrezDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Takahisa KawaguchiCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Setoh KazuyaGraduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan.
Tanika N KellyDivision of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Pirjo KomulainenKuopio Research Institute of Exercise Medicine, Kuopio, Finland.
Daniel LevyPopulation Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Henry J LinThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Peter Y LiuThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0003-2439-0915
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0002-4548-8500
Joseph B McCormickSchool of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA.ORCID 0000-0002-5844-8102
Hao MeiDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
James B MeigsDepartment of Medicine, Harvard Medical School, Boston, MA, USA.
Cristina MenniDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.ORCID 0000-0001-9790-0571
Kisung NamGraduate School of Data Science, Seoul National University, Seoul, South Korea.ORCID 0000-0002-7317-092X
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.ORCID 0000-0001-5047-4077
Natasha L PachecoLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Lauren E PettyDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Hannah G PolikowskyDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-6102-774X
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-7278-2190
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Olli T RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Stephen S RichDepartment of Genome Sciences, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-3872-7793
Renata L RihaDepartment of Sleep Medicine, The University of Edinburgh, Edinburgh, UK.
Lorenz RischFaculty of Medical Sciences, Institute for Laboratory Medicine, Private University in the Principality of Liechtenstein, Vaduz, Liechtenstein.
Martin RischCentral Laboratory, Cantonal Hospital Graubünden, Chur, Switzerland.
Edward A Ruiz-NarvaezDepartment of Nutritional Sciences, University of Michigan, Ann Arbor, MI, USA.
Rodney J ScottSchool of Biomedical Sciences and Pharmacy, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia.ORCID 0000-0001-7724-3404
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Jennifer A SmithSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3575-5468
Tamar SoferDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-8520-8860
Maris Teder-LavingEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.ORCID 0000-0002-5872-1850
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-5689-3448
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Guanchao WangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.
Ko Willems van DijkDepartment of Human Genetics, Leiden University Medical Center, Leiden, Netherlands.ORCID 0000-0002-2172-7394
Otis D WilsonBiomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs, Nashville, TN, USA.
Rui XiaBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Kristin L YoungDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ruiyuan ZhangDepartment of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0003-0037-411X
Jennifer E BelowDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-1346-1872
Carsten A BögerDepartment of Nephrology, University Hospital Regensburg, Regensburg, Germany.
David ConenPopulation Health Research Institute, Medicine, McMaster University, Hamilton, ON, Canada.
Simon R CoxDepartment of Psychology, The University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-4036-3642
Marcus DörrDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.ORCID 0000-0001-7471-475X
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0933-2410
Ervin R FoxJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Nora FranceschiniDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Sina A GharibPulmonary, Critical Care and Sleep Medicine, Medicine, University of Washington, Seattle, WA, USA.ORCID 0000-0002-2480-4367
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.ORCID 0000-0001-5696-0084
Sioban D HarlowDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Jiang HeDepartment of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-8286-9652
Elizabeth G HollidaySchool of Medicine and Public Health, College of Health Medicine and Wellbeing, University of Newcastle, New Lambton Heights, NSW, Australia.
Zoltan KutalikStatistical Genetics Group, Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
Timo A LakkaInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.
Deborah A LawlorMRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.ORCID 0000-0002-6793-2262
Seunggeun LeeGraduate School of Data Science, Seoul National University, Seoul, South Korea.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.ORCID 0000-0002-2555-4427
Changwei LiDepartment of Epidemiology, O'Donnell School of Public Health, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9203-304X
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-0703-0742
Reedik MägiEstonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.ORCID 0000-0001-6381-4296
Brenda Wjh PenninxDepartment of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, Netherlands.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-9717-8459
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.ORCID 0000-0001-7191-1723
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.ORCID 0000-0003-1949-2298
Tim D SpectorDepartment of Twin Research & Genetic Epidemiology, King's College London, London, UK.
Lynne E WagenknechtPublic Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1422-2993
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.ORCID 0000-0002-6523-4778
Kari E NorthDepartment of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-8903-0366
Myriam FornageBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.ORCID 0000-0003-0677-8158
Million Veteran Program
Adriana M HungBiomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626), Department of Veterans Affairs, Nashville, TN, USA.
Alisa K ManningClinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
James GaudermanDivision of Biostatistics, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Han ChenHuman Genetics Center, Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA.ORCID 0000-0002-9510-4923
Patricia B MunroeClinical Pharmacology and Precision Medicine, Queen Mary University of London, London, UK.
Dabeeru C RaoCenter for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Diana van HeemstDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands.
Susan RedlineDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-6585-1610
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, Netherlands.
Heming WangDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. hwang@bwh.harvard.edu.ORCID 0000-0002-1486-7495
Funding
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lona Mody, RAYMOND L YUNG · 2004 to 2026
$29.2MStatistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI William JAMES GAUDERMAN · 2016 to 2026
$25.5MA Multi-Ancestry Study of Gene-Lifestyle Interactions and Multi-Omics in Cardiometabolic TraitsR01HL156991 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2021 to 2024
$8.8MA Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3MInfrastructure for mentored access to CHS data and specimensR01HL172803 · NHLBI · UNIVERSITY OF WASHINGTON · PI James S Floyd, Michelle Christina Odden · 2025 to 2026
$2.7MMulti-omics study of ancestry enriched associations in Hispanics/LatinosR01HG013163 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nora Franceschini, Tamar Sofer · 2024 to 2026
$2.1MGenetics of Cardiovascular Disease in Chronic Kidney DiseaseR01HL163972 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRANCESCHINI, NORA, LI, YUN · 2022 to 2025
$1.9MMentored Training in Molecular Epidemiology of Chronic Kidney Disease in Diverse PopulationsK26DK138425 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nora Franceschini · 2023 to 2026
$277kCSRD VA I01 CX001897NCI NIH HHS P01 CA196569NHGRI NIH HHS R01 HG013163NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL156991NHLBI NIH HHS R01 HL163972NHLBI NIH HHS R01 HL172803NIA NIH HHS P30 AG024824NIDDK NIH HHS K26 DK138425U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL118305U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL156991U.S. Department of Veterans Affairs (Department of Veterans Affairs) CX001897
Abstract
Although both short and long sleep duration are associated with elevated hypertension risk, our understanding of their interplay with biological pathways governing blood pressure remains limited. To address this, we carried out genome-wide cross-population gene-by-short-sleep and long-sleep duration interaction analyses for three blood pressure traits (systolic, diastolic, and pulse pressure) in 811,405 individuals from diverse population groups. We discovered 22 novel gene-sleep duration interaction loci for blood pressure, mapped to 23 genes. Investigating these genes' functional implications shed light on neurological, thyroidal, bone metabolism, and hematopoietic pathways that necessitate future investigation for blood pressure management that caters to sleep health lifestyle. Non-overlap between short sleep (12) and long sleep (10) interactions underscores the plausible nature of distinct influences of both sleep duration extremes in cardiovascular health. Several of our loci are specific towards a particular population background or sex, emphasizing the importance of addressing heterogeneity entangled in gene-environment interactions, when considering precision medicine design approaches for blood pressure management.
Indexed as
Blood PressureSleepAdultAgedFemaleGene-Environment InteractionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansHypertensionMaleMiddle AgedPolymorphism, Single NucleotideSleep Duration
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