ArticleNature neuroscience2025
Human lifespan changes in the brain's functional connectome.
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Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
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69citing papers in PubMed, 1 pooled it
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis and meta-regression of diagnostic test accuracy of connectome-based predictive modeling in OCD.Brain imaging and behavior · 2026Pooled it
- Different functional connectivity gradients reflect aging and Alzheimer's disease.Nature neuroscience · 2026Article
- Cortical microarchitecture supports preadolescent functional brain network connectivity.bioRxiv : the preprint server for biology · 2026Article
- Heterogeneous structural brain signatures of methamphetamine and ketamine use disorders revealed by normative modeling.Molecular psychiatry · 2026Article
- Charting confidence in white matter brain charts: enabling study planning through stability validation.Journal of medical imaging (Bellingham, Wash.) · 2026Article
- Adolescent Hormonal Contraceptive Use in the Context of Brain Development and Depression Risk: A Review and Considerations for Future Research.Biological psychiatry global open science · 2026Review
- Development of functional topography of the default mode subnetworks revealed by precision mapping.Developmental cognitive neuroscience · 2026Article
- Longitudinal Associations of Structural and Functional Brain Connectivity With Dimensions of Psychopathology in Adolescence.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Multiscale brain development across the human lifespan.Communications biology · 2026Review
- Article
- Mapping the functional connectome between grey matter and white matter.Communications biology · 2026Article
- Structure-function dynamics in healthy cognitive aging: a graph signal processing approach.Brain structure & function · 2026Article
- Aging and metabolism contribute separately to brain-body health.PLoS biology · 2026Article
- The unity and diversity of functional brain connectivity underlying executive function tasks.Developmental cognitive neuroscience · 2026Article
- Developmental human brain connectome from fetal stage to early childhood.Developmental cognitive neuroscience · 2026Review
- An Orthogonal Semi-Nonnegative Matrix Factorization Method for Dynamic Functional Connectivity Analysis and Its Application to Schizophrenia.IEEE journal of biomedical and health informatics · 2026Article
- Brain maintenance biomarkers from structural and functional interactions in aging and neurodegeneration.Nature communications · 2026Article
- Lamellar Normative Modelling of the Hippocampus Across the Human Lifespan.bioRxiv : the preprint server for biology · 2026Article
- Functional brain growth trajectories across the first decade of life from a single longitudinal cohort.Research square · 2026Article
- Cerebellar growth is associated with domain-specific cerebral maturation and socio-linguistic behavior.Nature communications · 2026Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
72 authors.
Lianglong SunState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Tengda ZhaoState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0002-5160-8417
Xinyuan LiangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Mingrui XiaState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0003-4615-9132
Qiongling LiState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0001-6989-2981
Xuhong LiaoSchool of Systems Science, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0009-0000-0170-2520
Gaolang GongState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0001-5788-022X
Qian WangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Chenxuan PangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Qian YuState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Yanchao BiState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0002-0522-3372
Pindong ChenBrainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Rui ChenState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Yuan ChenDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID http://orcid.org/0009-0003-3747-2407
Taolin ChenDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Jingliang ChengDepartment of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.ORCID http://orcid.org/0000-0001-9944-8419
Yuqi ChengDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Zaixu CuiChinese Institute for Brain Research, Beijing, China.ORCID http://orcid.org/0000-0003-4385-8106
Zhengjia DaiState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Yao DengState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Yuyin DingState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Qi DongState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Dingna DuanState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Jia-Hong GaoCenter for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.ORCID http://orcid.org/0000-0002-9311-0297
Qiyong GongDepartment of Radiology, Huaxi MR Research Center (HMRRC), Institute of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0002-5912-4871
Ying HanDepartment of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.
Zaizhu HanState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0003-1751-6452
Chu-Chung HuangKey Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China.ORCID http://orcid.org/0000-0002-9096-9610
Ruiwang HuangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Ran HuoDepartment of Radiology, Peking University Third Hospital, Beijing, China.
Lingjiang LiDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
Ching-Po LinInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-6848-8776
Qixiang LinState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0002-1718-6855
Bangshan LiuDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
Chao LiuState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0003-1149-2314
Ningyu LiuState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Ying LiuDepartment of Radiology, Peking University Third Hospital, Beijing, China.
Yong LiuCenter for Artificial Intelligence in Medical Imaging, School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China.ORCID http://orcid.org/0000-0002-1862-3121
Jing LuState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Leilei MaState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Weiwei MenCenter for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.
Shaozheng QinState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0002-1859-2150
Jiang QiuKey Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.
Shijun QiuDepartment of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.ORCID http://orcid.org/0000-0002-6739-4265
Tianmei SiPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China.
Shuping TanBeijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School, Beijing, China.
Yanqing TangDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.ORCID http://orcid.org/0000-0003-4212-3212
Sha TaoState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Dawei WangDepartment of Radiology, Qilu Hospital of Shandong University, Ji'nan, China.
Fei WangDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, China.ORCID http://orcid.org/0000-0002-7650-6345
Jiali WangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Pan WangDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin University, Tianjin, China.
Xiaoqin WangKey Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.
Yanpei WangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Dongtao WeiKey Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China.
Yankun WuPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, China.
Peng XieChongqing Key Laboratory of Neurobiology, Chongqing, China.ORCID http://orcid.org/0000-0002-0081-6048
Xiufeng XuDepartment of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Yuehua XuState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Zhilei XuState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.ORCID http://orcid.org/0000-0002-5155-6346
Liyuan YangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Huishu YuanDepartment of Radiology, Peking University Third Hospital, Beijing, China.
Zilong ZengState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Haibo ZhangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Xi ZhangDepartment of Neurology, the Second Medical Centre, National Clinical Research Centre for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China.
Gai ZhaoState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Yanting ZhengDepartment of Radiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Suyu ZhongCenter for Artificial Intelligence in Medical Imaging, School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China.
Alzheimer’s Disease Neuroimaging Initiative
DIDA-MDD Working Group
MCADI
Yong HeState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China. yong.he@bnu.edu.cn.ORCID http://orcid.org/0000-0002-7039-2850
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MChangjiang Scholar Program of Chinese Ministry of Education (Changjiang Scholar Program of Ministry of Education of China) T2015027National Natural Science Foundation of China (National Science Foundation of China) 31221003National Natural Science Foundation of China (National Science Foundation of China) 31521063National Natural Science Foundation of China (National Science Foundation of China) 31830034National Natural Science Foundation of China (National Science Foundation of China) 32130045National Natural Science Foundation of China (National Science Foundation of China) 61633018National Natural Science Foundation of China (National Science Foundation of China) 81400890National Natural Science Foundation of China (National Science Foundation of China) 81471120National Natural Science Foundation of China (National Science Foundation of China) 81471251National Natural Science Foundation of China (National Science Foundation of China) 81571062National Natural Science Foundation of China (National Science Foundation of China) 81771344National Natural Science Foundation of China (National Science Foundation of China) 81901101National Natural Science Foundation of China (National Science Foundation of China) 81920108019National Natural Science Foundation of China (National Science Foundation of China) 81971690National Natural Science Foundation of China (National Science Foundation of China) 82021004National Natural Science Foundation of China (National Science Foundation of China) 82071998National Natural Science Foundation of China (National Science Foundation of China) 82172018National Natural Science Foundation of China (National Science Foundation of China) 82202245National Natural Science Foundation of China (National Science Foundation of China) 82327807National Natural Science Foundation of China (National Science Foundation of China) 82330058National Natural Science Foundation of China (National Science Foundation of China) 91649117National Natural Science Foundation of China (National Science Foundation of China) T2325006NIA NIH HHS U01 AG024904
Abstract
Functional connectivity of the human brain changes through life. Here, we assemble task-free functional and structural magnetic resonance imaging data from 33,250 individuals at 32 weeks of postmenstrual age to 80 years from 132 global sites. We report critical inflection points in the nonlinear growth curves of the global mean and variance of the connectome, peaking in the late fourth and late third decades of life, respectively. After constructing a fine-grained, lifespan-wide suite of system-level brain atlases, we show distinct maturation timelines for functional segregation within different systems. Lifespan growth of regional connectivity is organized along a spatiotemporal cortical axis, transitioning from primary sensorimotor regions to higher-order association regions. These findings elucidate the lifespan evolution of the functional connectome and can serve as a normative reference for quantifying individual variation in development, aging and neuropsychiatric disorders.
Indexed as
AgingBrainConnectomeLongevityNerve NetAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleHumansInfantMagnetic Resonance ImagingMale
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PMID
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.