ArticleNature aging2025
Regeneration leads to global tissue rejuvenation in aging sexual planarians.
Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Multiplexed gene expression analysis in dissociated and intact planarian flatworm tissues using in situ hybridization chain reaction.Biology open · 2026Article
- Article
- Regeneration: A planarian DIY fertility restoration guide.Current biology : CB · 2026Article
- Drift of positional identity drives reproductive aging in a long-lived regenerative animal.Current biology : CB · 2026Article
- The Sensory Basis of Planarian Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Molecular evolution of animal aging.The EMBO journal · 2026Review
- Regenerate to "Rejuvenate": Insights From Adult Resident Stem Cells of Aged Flatworms and Mice.Aging cell · 2025Review
- Unlocking longevity through the comparative biology of aging.Nature aging · 2025Review
- Systemic identification and characterization of the conserved core NuRD complex in planarian.Frontiers in aging · 2025Article
- Agelessness is possible under the disposable soma theory but system complexity makes it unlikely.Journal of theoretical biology · 2024Article
- Extraordinary model systems for regeneration.Development (Cambridge, England) · 2024Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
The possibility of reversing the adverse impacts of aging could significantly reduce age-related diseases and improve quality of life in older populations. Here we report that the sexual lineage of the planarian Schmidtea mediterranea exhibits physiological decline within 18 months of birth, including altered tissue architecture, impaired fertility and motility, and increased oxidative stress. Single-cell profiling of young and older planarian heads uncovered loss of neurons and muscle, increase of glia, and revealed minimal changes in somatic pluripotent stem cells, along with molecular signatures of aging across tissues. Remarkably, amputation followed by regeneration of lost tissues in older planarians led to reversal of these age-associated changes in tissues both proximal and distal to the injury at physiological, cellular and molecular levels. Our work suggests mechanisms of rejuvenation in both new and old tissues concurring with planarian regeneration, which may provide valuable insights for antiaging interventions.
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Registered trials
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