Evidence map›Paper›PMID 40181175›Full record

ArticleScientific reports2025

Environmental enrichment reverses noise induced impairments in learning and memory associated with the hippocampus in female rats.

Yutian Sun, Pengying An, Yongjian Cai, Wenjing Yang, Yue Fang, Hui Liu, Guimin Zhang, Ye Shan, Jie Wang, Yifan Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yutian Sun *Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
Pengying An *Key Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
Yongjian CaiKey Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
Wenjing YangKey Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
Yue FangKey Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
Hui LiuKey Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
Guimin ZhangKey Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
Ye ShanKey Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China.
Jie WangDepartment of Otolaryngology-Head and Neck Surgery, Wuhu Hospital, East China Normal University, Wuhu, 241000, China.
Yifan ZhangKey Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China. yfzhang@bio.ecnu.edu.cn.
Xiaoming ZhouKey Laboratory of Brain Functional Genomics of Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, School of Life Sciences, East China Normal University, Shanghai, 200062, China. xmzhou@bio.ecnu.edu.cn.

Funding

National Natural Science Foundation of China 32161160325Project of Shanghai Science and Technology Commission 22YF1411500
6 · The paper itself

Abstract

Environmental enrichment (EE) has positive effects on brain function and behavior in both healthy and behaviorally impaired animals. In earlier studies, we showed that rats exposed to noise during early development exhibited deficits in learning and memory associated with the hippocampus. In this study, we investigated whether EE provided during adulthood can reverse such noise-induced impairments. We found that four weeks of EE substantially improved learning and memory in adult female rats exposed to noise during early development. The behavioral changes observed after EE were accompanied by the restoration of parvalbumin-positive (PV+) inhibitory interneurons in the hippocampal subregions. EE also reversed noise-induced reductions in hippocampal long-term potentiation (LTP) of synaptic connections, a mechanism essential for learning and memory processing. However, an enriched environment that lacked social interaction had little effect on restoring LTP in noise-exposed rats. These findings suggest that EE effectively mitigates hippocampal impairments that stem from early noise exposure, with social interaction playing a crucial role in this recovery process.

Indexed as

EnvironmentHippocampusLearningMemoryNoiseAnimalsFemaleInterneuronsLong-Term PotentiationRatsEnvironmental enrichmentHippocampus-related behaviorInhibitory interneuronNoise exposureRat

Identifiers

PMID40181175
PMCPMC11968901

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.